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New Insight into Nutrient Response and Adaptation: From Molecular Mechanism...
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New Insight into Nutrient Response and Adaptation: From Molecular Mechanism to Metabolic Reprogramming

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2022) | Viewed by 7518

Special Issue Editors

Dr. Serena Rinaldo

E-Mail Website1 Website2
Guest Editor
Department of Biochemical Sciences “A. Rossi Fanelli” Sapienza, University of Rome, P.le Aldo Moro 5, 00185 Rome, Italy
Interests: bacterial second messenger; redox biochemistry; nucleotides; energy metabolism; c-di-GMP; heme proteins; nitric oxide; protein nucleic acid interaction; arginine biochemistry; isothermal titration calorimetry
Dr. Alessio Paone

E-Mail Website1 Website2
Guest Editor
Department of Biochemical Sciences “A. Rossi Fanelli” – Sapienza, University of Rome, P.le Aldo Moro 5, 00185 Rome (I), Italy
Interests: cancer cell biochemistry; one carbon metabolism; serine and glycine biochemistry; Toll-like receptor; protein nucleic acid interaction; energy metabolism; metastasis metabolism; microenvironment interaction

Special Issue Information

Dear Colleagues,

The large part of cellular processes among both prokaryotes and eukaryotes is related to the ability to perceive and respond to environmental nutrient levels and re-adapt to their variation. The different strategies which have evolved to detect intracellular and extracellular anabolic and energetic precursors levels are integrated within the same cell and coordinated at the multicellular levels (in terms of cellular population or within the organism) via signaling messengers.

Since the alteration in such processes leads to a pathogenic readout, understating the molecular mechanism and the metabolic effect of nutrient response is crucial to develop novel strategies to restore the cellular homeostasis.

This Special Issue aims at presenting novel data focused on both prokaryotic and eukaryotic nutrient response spanning from the molecular mechanism of protein function to cellular adaptation, including metabolic re-programming and the cell phenotype in both physiological and pathological contexts.

Dr. Serena Rinaldo
Dr. Alessio Paone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Published Papers (2 papers)

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Research

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13 pages, 1640 KiB  
Article
AMPK Phosphorylation Is Controlled by Glucose Transport Rate in a PKA-Independent Manner
by Riccardo Milanesi, Farida Tripodi, Jacopo Vertemara, Renata Tisi and Paola Coccetti
Int. J. Mol. Sci. 2021, 22(17), 9483; https://doi.org/10.3390/ijms22179483 - 31 Aug 2021
Cited by 5 | Viewed by 3023
Abstract
To achieve growth, microbial organisms must cope with stresses and adapt to the environment, exploiting the available nutrients with the highest efficiency. In Saccharomyces cerevisiae, Ras/PKA and Snf1/AMPK pathways regulate cellular metabolism according to the supply of glucose, alternatively supporting fermentation or [...] Read more.
To achieve growth, microbial organisms must cope with stresses and adapt to the environment, exploiting the available nutrients with the highest efficiency. In Saccharomyces cerevisiae, Ras/PKA and Snf1/AMPK pathways regulate cellular metabolism according to the supply of glucose, alternatively supporting fermentation or mitochondrial respiration. Many reports have highlighted crosstalk between these two pathways, even without providing a comprehensive mechanism of regulation. Here, we show that glucose-dependent inactivation of Snf1/AMPK is independent from the Ras/PKA pathway. Decoupling glucose uptake rate from glucose concentration, we highlight a strong coordination between glycolytic metabolism and Snf1/AMPK, with an inverse correlation between Snf1/AMPK phosphorylation state and glucose uptake rate, regardless of glucose concentration in the medium. Despite fructose-1,6-bisphosphate (F1,6BP) being proposed as a glycolytic flux sensor, we demonstrate that glucose-6-phosphate (G6P), and not F1,6BP, is involved in the control of Snf1/AMPK phosphorylation state. Altogether, this study supports a model by which Snf1/AMPK senses glucose flux independently from PKA activity, and thanks to conversion of glucose into G6P. Full article
(This article belongs to the Special Issue New Insight into Nutrient Response and Adaptation: From Molecular Mechanism to Metabolic Reprogramming)
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Review

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14 pages, 1768 KiB  
Review
Nutrient Sensing and Biofilm Modulation: The Example of L-arginine in Pseudomonas
by Chiara Scribani Rossi, Laura Barrientos-Moreno, Alessio Paone, Francesca Cutruzzolà, Alessandro Paiardini, Manuel Espinosa-Urgel and Serena Rinaldo
Int. J. Mol. Sci. 2022, 23(8), 4386; https://doi.org/10.3390/ijms23084386 - 15 Apr 2022
Cited by 20 | Viewed by 3557
Abstract
Bacterial biofilm represents a multicellular community embedded within an extracellular matrix attached to a surface. This lifestyle confers to bacterial cells protection against hostile environments, such as antibiotic treatment and host immune response in case of infections. The Pseudomonas genus is characterised by [...] Read more.
Bacterial biofilm represents a multicellular community embedded within an extracellular matrix attached to a surface. This lifestyle confers to bacterial cells protection against hostile environments, such as antibiotic treatment and host immune response in case of infections. The Pseudomonas genus is characterised by species producing strong biofilms difficult to be eradicated and by an extraordinary metabolic versatility which may support energy and carbon/nitrogen assimilation under multiple environmental conditions. Nutrient availability can be perceived by a Pseudomonas biofilm which, in turn, readapts its metabolism to finally tune its own formation and dispersion. A growing number of papers is now focusing on the mechanism of nutrient perception as a possible strategy to weaken the biofilm barrier by environmental cues. One of the most important nutrients is amino acid L-arginine, a crucial metabolite sustaining bacterial growth both as a carbon and a nitrogen source. Under low-oxygen conditions, L-arginine may also serve for ATP production, thus allowing bacteria to survive in anaerobic environments. L-arginine has been associated with biofilms, virulence, and antibiotic resistance. L-arginine is also a key precursor of regulatory molecules such as polyamines, whose involvement in biofilm homeostasis is reported. Given the biomedical and biotechnological relevance of biofilm control, the state of the art on the effects mediated by the L-arginine nutrient on biofilm modulation is presented, with a special focus on the Pseudomonas biofilm. Possible biotechnological and biomedical applications are also discussed. Full article
(This article belongs to the Special Issue New Insight into Nutrient Response and Adaptation: From Molecular Mechanism to Metabolic Reprogramming)
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