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Novel Nano-Drug Delivery Systems and Their Application towards Brain Targeting
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Novel Nano-Drug Delivery Systems and Their Application towards Brain Targeting

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2844

Special Issue Editors

Dr. Rameshwar Patil

E-Mail Website
Guest Editor
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Interests: brain tumor; Alzheimer disease; blood-brain barrier; glioblastoma; nanomedicine; tumor-microenvironment; biomarker
Prof. Dr. Eleonora Russo

E-Mail Website
Guest Editor
Department of Pharmacy, University of Genova, 16132 Genova, Italy
Interests: drug delivery; nanomedicine; hydrogels; antioxidant compound; cancer; pediatric therapy; nanoparticles; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

The aim of this Special Issue in “Novel Nano-Drug Delivery Systems and Their Application towards Brain Targeting” is to focus on the recent progresses in the delivery of drugs to the central nervous system (CNS) for brain targeting. Articles addressing blood–brain barrier (BBB) drug delivery with an emphasis on active targeting will be encouraged. Exportation of drug delivery across the BBB has become vital in the advancement of novel strategies for the treatment of neurological diseases such as Alzheimer’s disease, Parkinson’s disease, stroke, and primary and metastatic brain cancers. Based on recent reports, more than 90% of therapeutic agents for neurological diseases failed to enter clinical trials due to poor brain penetration. Therefore, it is essential that future BBB drug delivery innovations focus on exploring the mechanisms of drug transport across the BBB and enhance knowledge of the brain microvasculature and the integrity of the BBB. Novel Nano-Drug Delivery Systems have emerged as a promising way to tackle this problem.

Dr. Rameshwar Patil
Prof. Dr. Eleonora Russo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • blood–brain barrier
  • central nervous system
  • nano-drug
  • drug delivery
  • Alzheimer’s disease
  • Parkinson’s disease
  • stroke
  • brain cancers

Published Papers (1 paper)

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Review

30 pages, 2993 KiB  
Review
Delivery of Theranostic Nanoparticles to Various Cancers by Means of Integrin-Binding Peptides
by Elena A. Egorova and Maxim P. Nikitin
Int. J. Mol. Sci. 2022, 23(22), 13735; https://doi.org/10.3390/ijms232213735 - 08 Nov 2022
Cited by 9 | Viewed by 2524
Abstract
Active targeting of tumors is believed to be the key to efficient cancer therapy and accurate, early-stage diagnostics. Active targeting implies minimized off-targeting and associated cytotoxicity towards healthy tissue. One way to acquire active targeting is to employ conjugates of therapeutic agents with [...] Read more.
Active targeting of tumors is believed to be the key to efficient cancer therapy and accurate, early-stage diagnostics. Active targeting implies minimized off-targeting and associated cytotoxicity towards healthy tissue. One way to acquire active targeting is to employ conjugates of therapeutic agents with ligands known to bind receptors overexpressed onto cancer cells. The integrin receptor family has been studied as a target for cancer treatment for almost fifty years. However, systematic knowledge on their effects on cancer cells, is yet lacking, especially when utilized as an active targeting ligand for particulate formulations. Decoration with various integrin-targeting peptides has been reported to increase nanoparticle accumulation in tumors ≥ 3-fold when compared to passively targeted delivery. In recent years, many newly discovered or rationally designed integrin-binding peptides with excellent specificity towards a single integrin receptor have emerged. Here, we show a comprehensive analysis of previously unreviewed integrin-binding peptides, provide diverse modification routes for nanoparticle conjugation, and showcase the most notable examples of their use for tumor and metastases visualization and eradication to date, as well as possibilities for combined cancer therapies for a synergetic effect. This review aims to highlight the latest advancements in integrin-binding peptide development and is directed to aid transition to the development of novel nanoparticle-based theranostic agents for cancer therapy. Full article
(This article belongs to the Special Issue Novel Nano-Drug Delivery Systems and Their Application towards Brain Targeting)
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