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Gels
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Gel Role in the World of the Cosmetic Research
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Gel Role in the World of the Cosmetic Research

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 20 July 2024 | Viewed by 7627

Special Issue Editors

Prof. Dr. Carla Villa

E-Mail Website
Guest Editor
Section of Medicinal and Cosmetic Chemistry, Department of Pharmacy, University of Genova, Viale Benedetto XV, 3-16132 Genova, Italy
Interests: gels; cosmetic technology; cosmetic chemistry; green chemistry; green extractions
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Eleonora Russo

E-Mail Website
Guest Editor
Section of Medicinal and Cosmetic Chemistry, Department of Pharmacy, University of Genova, Viale Benedetto XV, 3-16132 Genova, Italy
Interests: gels; pharmaceutical technology; mucoadhesion; nanotechnology; drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a manuscript regarding the world of gels in the cosmetic field. The term “gel” encompasses several concepts, from new materials (i.e., natural and synthetic polymers) to new applications related to studies on the rheological behaviour of gelled systems. Moreover, nowadays a “cosmetic gel” can play a fundamental role as a safety tool in a pandemic time.

The development of the most performing cosmetic formulation needs multidisciplinary knowledge dealing with raw materials chemistry, rheological studies, skin wellness and safety.

In this regard, this Special Issue aims to explore all the cosmetic research involving gels and calls for manuscripts that can enhance the following fields regarding:

  • innovative synthetic polymers and biopolymers useful in different cosmetic systems from solutions to emulsions

  • new formulations, focusing on interaction of ingredients and the rheological behaviour depending on compounds amounts and conditions. This topic can include stability tests and in vitro cytotoxicity assays

  • research that enhances sustainability, human health and safety, by studying new eco-friendly pathways in gel formulation

It is our pleasure to receive a contribution to this Special Issue. Full papers, communications, and reviews are all welcome.

Prof. Dr. Carla Villa
Prof. Dr. Eleonora Russo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gel
  • rheology
  • cosmetics
  • biopolymers
  • gelling agents
  • healthcare
  • sustainable formulations
  • safety

Published Papers (5 papers)

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Research

18 pages, 20759 KiB  
Article
Alginate Gel Encapsulated with Enzybiotics Cocktail Is Effective against Multispecies Biofilms
by Daria V. Vasina, Nataliia P. Antonova, Elena V. Shidlovskaya, Nadezhda A. Kuznetsova, Alexander V. Grishin, Elizaveta A. Akoulina, Ekaterina A. Trusova, Anastasiya M. Lendel, Elena P. Mazunina, Sofia R. Kozlova, Andrei A. Dudun, Anton P. Bonartsev, Vladimir G. Lunin and Vladimir A. Gushchin
Gels 2024, 10(1), 60; https://doi.org/10.3390/gels10010060 - 14 Jan 2024
Viewed by 1146
Abstract
The development of new and effective antibacterials for pharmaceutical or cosmetic skin care that have a low potential for the emergence and expansion of bacterial resistance is of high demand in scientific and applied research. Great hopes are placed on alternative agents such [...] Read more.
The development of new and effective antibacterials for pharmaceutical or cosmetic skin care that have a low potential for the emergence and expansion of bacterial resistance is of high demand in scientific and applied research. Great hopes are placed on alternative agents such as bactericidal peptidoglycan hydrolases, depolymerases, etc. Enzybiotic-based preparations are being studied for the treatment of various infections and, among others, can be used as topical formulations and dressings with protein-polysaccharide complexes. Here, we investigate the antibiofilm properties of a novel enzybiotic cocktail of phage endolysin LysSi3 and bacteriocin lysostaphin, formulated in the alginate gel matrix and its ability to control the opportunistic skin-colonizing bacteria Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae, as well as mixed-species biofilms. Our results propose that the application of SiL-gel affects different components of biofilm extracellular polymeric substances, disrupts the matrix, and eliminates the bacteria embedded in it. This composition is highly effective against biofilms composed of Gram-negative and Gram-positive species and does not possess significant cytotoxic effects. Our data form the basis for the development of antibacterial skin care products with a gentle but effective mode of action. Full article
(This article belongs to the Special Issue Gel Role in the World of the Cosmetic Research)
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11 pages, 1778 KiB  
Article
Gauging Quince Phytonutrients and Its 4% Emulgel Effect on Amplifying Facial Skin Moisturizing Potential
by Tanzila Khiljee, Naveed Akhtar, Sonia Khiljee, Bushra Khiljee, Hafiz Majid Rasheed, Siddique Akber Ansari, Hamad M. Alkahtani and Irfan Aamer Ansari
Gels 2023, 9(12), 934; https://doi.org/10.3390/gels9120934 - 28 Nov 2023
Cited by 2 | Viewed by 985
Abstract
Background: The aim of this study was to evaluate the moisturizing efficacy of quince fruit, used in folk medicine. For this purpose, the phytoconstituents of Cydonia oblonga fruit extract, like phenolics and flavonoids, were determined. A stable cosmetic emulgel containing 4% Cydonia oblonga [...] Read more.
Background: The aim of this study was to evaluate the moisturizing efficacy of quince fruit, used in folk medicine. For this purpose, the phytoconstituents of Cydonia oblonga fruit extract, like phenolics and flavonoids, were determined. A stable cosmetic emulgel containing 4% Cydonia oblonga fresh fruit extract was formulated and subjected to in vivo evaluation compared with a control. Materials and Methods: Cydonia oblonga fresh fruit extract was evaluated for tyrosinase activity and phenolic and flavonoid content. A stable emulgel containing 4% Cydonia oblonga fresh fruit extract was formulated and tested in a skin irritation test. After this, in vivo tests of erythema, moisture, sebum, and skin elasticity were conducted. The in vivo evaluation was a randomized and single-blind study. Thirteen healthy female volunteers were selected for a three-month study period. Results: Cydonia oblonga fruit extract showed good phenolic and flavonoid content, which was associated with its good antioxidant and tyrosinase-inhibiting activity. Cydonia oblonga containing the emulgel showed a reduction in sebum and erythema, while the elasticity and moisture content showed increments in their levels after the three-month application of the formulation. The fruit contains chlorogenic acid and many sugars, which might account for its anti-inflammatory and sebum reduction effects; it is also capable of enhancing the skin’s hydration level and decreasing skin sagging by enhancing its elasticity. Conclusion: The emulgel loaded with Cydonia oblonga fresh fruit extract is verified regarding its folklore status as a moisturizing agent that enhances the facial skin cells’ resilience potential. Full article
(This article belongs to the Special Issue Gel Role in the World of the Cosmetic Research)
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14 pages, 1985 KiB  
Article
Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis
by Aqsa Afzal, Syed Nisar Hussain Shah, Hina Javed, Asma Mumtaz, Javeria Saeed, Hafiz Majid Rasheed, Rabia Arshad, Siddique Akber Ansari, Hamad M. Alkahtani and Irfan Aamer Ansari
Gels 2023, 9(10), 832; https://doi.org/10.3390/gels9100832 - 20 Oct 2023
Viewed by 1482
Abstract
Background: Dermatitis is skin disorder that is complicated by recurrent infections of skin by bacteria, viruses, and fungi. Spilanthol is an active constituent of Spilanthes acmella, which possess strong anti-bacterial properties. The purpose of this study was to develop a herbal emulgel [...] Read more.
Background: Dermatitis is skin disorder that is complicated by recurrent infections of skin by bacteria, viruses, and fungi. Spilanthol is an active constituent of Spilanthes acmella, which possess strong anti-bacterial properties. The purpose of this study was to develop a herbal emulgel for the treatment of dermal bacterial infections, as microscopic organisms have created solid resistance against anti-microbials. Methods: Emulgels were prepared and characterized for parameters such as physical examination, rheological studies, spreading coefficient, bio-adhesive strength measurement, extrudability study, antibacterial activity, FTIR analysis, in vitro drug dissolution, and ex vivo permeation studies. Result: With a statistically significant p-value = 0.024, 100% antibacterial activity was observed by F4 against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli (mean ± S.D) (25.33 ± 0.28, 27.33 ± 0.5, and 27 ± 0.5). However, maximum antibacterial effect 100% formulations produced zones of inhibitions against E. colip-value = 0.001. The mean zone of inhibition produced by F4 was greatest among all at 26.44 ± 0.37 mm (mean ± S.D). The F4 formulation produced a maximum percentage dissolution, permeation, and flux of 86.35 ± 0.576, 55.29 ± 0.127%, and 0.5532 ug/cm2/min, respectively. Conclusions: The present study therefore, suggests the use of S. acmella extract and olive oil containing emulgel for treating bacterial skin infections. Full article
(This article belongs to the Special Issue Gel Role in the World of the Cosmetic Research)
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15 pages, 3376 KiB  
Article
Balsam Poplar Buds Extracts-Loaded Gels and Emulgels: Development, Biopharmaceutical Evaluation, and Biological Activity In Vitro
by Monika Jokubaite, Greta Pukenaite, Mindaugas Marksa and Kristina Ramanauskiene
Gels 2023, 9(10), 821; https://doi.org/10.3390/gels9100821 - 17 Oct 2023
Viewed by 1087
Abstract
Balsam poplar buds have been used for wound healing and treating irritated skin in traditional medicine. Balsam poplar buds extracts exhibit anti-inflammatory, antioxidant, and antimicrobial effects. In recent years, scientific research has begun to validate some of these traditional uses, leading to an [...] Read more.
Balsam poplar buds have been used for wound healing and treating irritated skin in traditional medicine. Balsam poplar buds extracts exhibit anti-inflammatory, antioxidant, and antimicrobial effects. In recent years, scientific research has begun to validate some of these traditional uses, leading to an increased interest in balsam poplar buds as a potential source of natural remedies in modern medicine. The study aims to simulate semi-solid pharmaceutical forms with balsam poplar buds extract and evaluate their quality through biopharmaceutical research. The active compounds identified in Lithuanian poplar buds were p-coumaric acid, cinnamic acid, caffeic acid, galangin, pinocembrin, pinobanksin, and salicin. In gels, pH values ranged from 5.85 ± 0.05 to 5.95 ± 0.07. The determined pH values of emulgels ranged from 5.13 ± 0.05 to 5.66 ± 0.15. After 6 h, the release of active compounds from gels and emulgels ranged from 47.40 ± 2.41% to 71.17 ± 3.54. p-coumaric acid dominates in the balsam poplar buds extracts. The pH values of the prepared sem-solid pharmaceutical forms are suitable for use on the skin. The viscosity of the formulations depends on the amount of gelling agent. All formulations showed antioxidant activity. It is relevant to conduct a more extensive study on the influence of the chosen carrier on the release of active compounds from semi-solid formulations with an extract of balsam poplar buds. Full article
(This article belongs to the Special Issue Gel Role in the World of the Cosmetic Research)
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23 pages, 3450 KiB  
Article
Design of Injectable Bioartificial Hydrogels by Green Chemistry for Mini-Invasive Applications in the Biomedical or Aesthetic Medicine Fields
by Rossella Laurano, Monica Boffito, Claudio Cassino, Francesco Liberti, Gianluca Ciardelli and Valeria Chiono
Gels 2023, 9(1), 59; https://doi.org/10.3390/gels9010059 - 11 Jan 2023
Cited by 5 | Viewed by 1975
Abstract
Bioartificial hydrogels are hydrophilic systems extensively studied for regenerative medicine due to the synergic combination of features of synthetic and natural polymers. Injectability is another crucial property for hydrogel mini-invasive administration. This work aimed at engineering injectable bioartificial in situ cross-linkable hydrogels by [...] Read more.
Bioartificial hydrogels are hydrophilic systems extensively studied for regenerative medicine due to the synergic combination of features of synthetic and natural polymers. Injectability is another crucial property for hydrogel mini-invasive administration. This work aimed at engineering injectable bioartificial in situ cross-linkable hydrogels by implementing green and eco-friendly approaches. Specifically, the versatile poly(ether urethane) (PEU) chemistry was exploited for the development of an amphiphilic PEU, while hyaluronic acid was selected as natural component. Both polymers were functionalized to expose thiol and catechol groups through green water-based carbodiimide-mediated grafting reactions. Functionalization was optimized to maximize grafting yield while preserving group functionality. Then, polymer miscibility was studied at the macro-, micro-, and nano-scale, suggesting the formation of hydrogen bonds among polymeric chains. All hydrogels could be injected through G21 and G18 needles in a wide temperature range (4–25 °C) and underwent sol-to-gel transition at 37 °C. The addition of an oxidizing agent to polymer solutions did not improve the gelation kinetics, while it negatively affected hydrogel stability in an aqueous environment, suggesting the occurrence of oxidation-triggered polymer degradation. In the future, the bioartificial hydrogels developed herein could find application in the biomedical and aesthetic medicine fields as injectable formulations for therapeutic agent delivery. Full article
(This article belongs to the Special Issue Gel Role in the World of the Cosmetic Research)
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