Revealing New Molecular Mechanisms in Medicinal Chemistry
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 1455
Special Issue Editor
Special Issue Information
Dear Colleagues,
The current arsenal of US FDA-approved drugs targets nearly 1000 human and pathogen-derived biomolecules. While annual new drug approvals continue at a steady rate, with 2023 marking the greatest number of approvals in three decades, drugs with novel mechanisms of action mark only a subset of these approvals. Targeting unique processes within disease states remains crucial for combating drug resistance, therapeutic failures in patient subgroups, and stratified therapeutic efficacy. Innovative mechanism-based drug design often requires annotating previously undescribed biomolecular targets. This Special Issue in the International Journal of Molecular Sciences highlights timely mechanistic discoveries in pharmacology, regardless of disease state, in emerging drug discovery campaigns. Molecular mechanisms of medicinal chemistry are defined as the biomolecular interactions between a pharmacological lead and target that elicit the desired physiological response. This Special Issue will platform exciting breakthroughs in the development of next-generation competitive and uncompetitive modulators, allosteric and covalent inhibitors, ligands with diverse pharmacokinetics, and newly defined polypharmacologic approaches, among others. Submitted manuscripts should include a detailed mechanistic evaluation of drug action. Submissions relating to all disease states are welcome.
Dr. Margaret E. Olson
Guest Editor
Manuscript Submission Information
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Keywords
- pharmacology
- pharmacokinetics
- covalent
- competitive
- uncompetitive
- agonist
- antagonist
- drug development
- mechanism of action
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