Recent Progress and Perspectives in Multiple Sclerosis

Dear Colleagues,

Multiple sclerosis (MS) is one of the most common and invalidating neurological diseases, involving mainly young adults and for which a definitive cure is not yet available. Although identifying patients at high risk of disease activity and disability progression is still a major unmet need, scientific research has been particularly prolific in recent years. We have observed substantial progress in the knowledge about the immunopathogenesis of the disease, including but not limited to the EBV studies. The concept of progression independent of relapse “PIRA” has emerged as the hallmark of such a “Smouldering” disease, which has been linked with meningeal inflammation and chronic active lesions. Several biomarkers have been associated with these pathological processes, and the role of microglia is currently under investigation. This Special Issue aims to summarize the new immunopathological and therapeutic advances with a special interest in smouldering disease and disability progression. Original research articles, review articles, and short communications within (but not restricted to) the described research fields are welcome.

Dr. Massimiliano Calabrese
Dr. Massimiliano Di Filippo
Guest Editors

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