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Enhanced Anticancer Properties of Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (20 July 2025) | Viewed by 577

Special Issue Editors


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Guest Editor
Department of Internal Medicine, Institute of Medical Science, Gyeongsang National University Hospital, College of Medicine, Gyeongsang National University, 15 Jinju-daero 816 Beon-gil, Jinju 52727, Republic of Korea
Interests: cancer cell biology; natual products; anticancer properties; cell death mechanism; cell morphology; proteomics; bioinformatics; signal transduction; drug resistance; chemotherapy
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Guest Editor
Department of Internal Medicine, Institute of Medical Science, Gyeongsang National University Hospital, College of Medicine, Gyeongsang National University, 15 Jinju-daero 816 Beon-gil, Jinju 52727, Republic of Korea
Interests: cancer cell biology; natual products; anticancer properties; cell death mechanism; cell morphology; proteomics; bioinformatics; signal transduction; drug resistance; chemotherapy

Special Issue Information

Dear Colleagues,

Natural products derived from plants demonstrate various biological activities, including antioxidant, anti-inflammatory, and anticancer properties, depending on their chemical structure and cellular circumstance. Recent studies suggest that the combination treatment of anticancer drugs with lower toxicity may be a more effective chemotherapeutic strategy than single treatment of a high dosage. The aim of this Special Issue is to reveal the enhanced anticancer properties of natural products using a new combination treatment of natural products and different types of chemotherapeutic agents in various types of cancer cells, including drug-resistant stable cells. In this study, a significant anticancer mechanism associated with the enhanced anticancer properties of natural products must be elucidated using common cell-based methods such as Western blot analysis.

In addition, unknown signal transduction mediators involved in the enhanced anticancer mechanism by combination treatment may be identified through proteomic analysis. Especially, the enhanced anticancer properties of natural products through combination treatment may be proven by investigating the effects of potential inhibitors. These results could be used for a new chemotherapeutic strategy to improve anticancer efficacy with low toxicity in various types of cancer treatments and to overcome drug resistance. We look forward to your cooperation in this Special Issue.

Dr. Won Sup Lee
Dr. Eun Joo Jung
Guest Editors

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Keywords

  • natural products
  • anticancer properties
  • chemotherapeutc agent
  • combination treatment
  • enhanced anticancer mechanism
  • signal transduction mediators
  • inhibitor effect
  • drug resistance
  • chemotherapy

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Published Papers (1 paper)

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Research

27 pages, 11354 KB  
Article
Tetraarsenic Hexoxide Enhanced the Anticancer Effects of Artemisia annua L. Polyphenols by Inducing Autophagic Cell Death and Apoptosis in Oxalplatin-Resistant HCT116 Colorectal Cancer Cells
by Eun Joo Jung, Hye Jung Kim, Sung Chul Shin, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong, Choong Won Kim and Won Sup Lee
Int. J. Mol. Sci. 2025, 26(16), 7661; https://doi.org/10.3390/ijms26167661 - 8 Aug 2025
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Abstract
It was reported that polyphenols extracted from Korean Artemisia annua L. (pKAL) have higher anticancer effects in oxaliplatin-resistant (OxPt-R) HCT116 cells than in HCT116 cells. In this study, it was tested whether and how As4O6 enhances anticancer effects of pKAL [...] Read more.
It was reported that polyphenols extracted from Korean Artemisia annua L. (pKAL) have higher anticancer effects in oxaliplatin-resistant (OxPt-R) HCT116 cells than in HCT116 cells. In this study, it was tested whether and how As4O6 enhances anticancer effects of pKAL in HCT116 and HCT116-OxPt-R colorectal cancer cells. The CCK-8 assay, phase-contrast microscopy, and colony formation assay revealed that As4O6 enhanced anticancer effects of pKAL, with induction of nuclear deformity and intracytoplasmic vesicle formation in both cells. Western blot analysis revealed that co-treatment with As4O6 and pKAL significantly decreased the expression of NF-kB, EGFR, cyclin D1, CD44, and β-catenin, and upregulated the expression of p62 and LC3B in both cells. It also induced the activation of caspase-8 and γ-H2AX and the cleavage of β-catenin, PARP1, lamin A/C, and p62. These phenomena were inhibited by wortmannin, and further suppressed by co-treatment of wortmannin with an ROS inhibitor, N-acetyl cysteine. This study suggests that As4O6 enhanced the anticancer effects of pKAL by inducing autophagic cell death accompanied by apoptosis in both parental HCT116 and HCT116-OxPt-R cells. It also suggests that ROS generation and the downregulation of AKT, NF-κB p65, cyclin D1, EGFR, and β-catenin may play an important role in the As4O6-enhanced anticancer effect of pKAL. Full article
(This article belongs to the Special Issue Enhanced Anticancer Properties of Natural Products)
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