Targeting Apoptosis Pathways in Cancer

Dear Colleagues,

This Special Issue, “Targeting Apoptosis Pathways in Cancer”, will cover a selection of recent research topics and current review articles related to the intracellular signaling of resistance to apoptosis in cancer. Up-to-date review articles, commentaries, and experimental papers are all welcome.

Programmed cell death or apoptosis is a natural mechanism by which organisms control the number of cells. It plays an important role in embryonic development and in maintaining cell homeostasis. Deregulation of apoptosis machinery induces resistance to apoptosis. This resistance is characterized by inhibition of cell death triggering or delay in cell death unfolding in response to an apoptotic stimulus. Apoptosis resistance plays an important role in tumor development. Uncontrolled cell proliferation combined with resistance to apoptosis is both necessary and sufficient for tumor progression to a malignant phenotype. Although there are several mechanisms by which cells escape apoptosis, the majority of these lead to an inability for the cell to trigger the intrinsic pathway of apoptosis (called the mitochondrial pathway). Despite numerous studies of the survival pathways in the apoptosis resistance mechanism, the signaling pathways involved have not yet been fully elucidated and there are disparities regarding their role in this mechanism.

Prof. Dr. Bertrand Liagre
Guest Editor

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