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Molecular Insight into Approaches against Cystic Fibrosis Infections

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 119

Special Issue Editor

Special Issue Information

Dear Colleagues,

Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder caused by mutations in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR). Patients with cystic fibrosis suffer from problems in the respiratory system, pancreas, intestine and other organs, mainly related to increased mucus viscosity due to abnormal chlorine excretion. Lung disease is the main cause of reduced life expectancy and death in patients with CF. Moreover, because various bacteria can colonize the thick mucus, these patients mostly present with complications caused by infections in the respiratory tract, which are often difficult to eradicate. Indeed, the main pathogens, which include among other Staphylococcus aureus, Pseudomonas aeruginosa, Burkholderia cepacia complex, non-tuberculous Mycobacteria are usually naturally resistant to the antibiotics used in the clinic due to several factors, thus difficult to eradicate. Consequently, novel drugs as well as the development of alternative strategies (i.e., nitric oxide, antimicrobial peptides, phage therapy, vaccines, etc.) are urgently needed.

In this context, this Special Issue aims to collect original research as well as review articles covering all molecular aspects of research in the field of infections in Cystic Fibrosis.

This Special Issue is supervised by Dr. Chiarelli Laurent and assisted by our Topical Advisory Panel Member Giovanni Stelitano (University of Pavia).

Dr. Chiarelli Laurent
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • cystic fibrosis
  • infections
  • multi-drug resistant pathogens
  • new drugs
  • anti-virulence compounds
  • phage therapy
  • vaccines

Published Papers

This special issue is now open for submission.
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