Bioactive Compounds and Therapeutic Targets in Prostate Cancer: 2nd Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (20 April 2025) | Viewed by 469
Special Issue Editor
Interests: prostate cancer; phytochemicals; dietary alkaloids; prebiotics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Globally, prostate cancer is one of the leading causes of death in men. The routine intake of bioactive compounds from various sources such as plants, diet, and marine organisms could be potentially beneficial in reducing the incidence and rates of death, as prostate cancer is characterized by a long latency period from the initiation of prostatic intraepithelial neoplasia to the development of adenocarcinoma. Although androgen deprivation therapy is the mainstay treatment, there is increased risk of patients developing lethal castration-resistant prostate cancer and treatment-induced neuroendocrine prostate cancer, in addition to experiencing severe side effects. There is increasing evidence that bioactive compounds could serve as alternative treatments or could be used as an adjunct therapy with conventional treatments to improve the quality of life and longevity of patients.
This Special Issue invites the submission of original research and review articles focused on bioactive compounds that have targets including androgen receptor (AR), AR variants (e.g., AR-V7), PI3K/Akt, mTOR, NF-kB, TGFbeta, EMT, transcription factors (e.g., c-Myc, N-Myc, STAT3, STAT5), mTOR, Wnt-beta catenin, Notch1, HDAC, DNMT3, etc., in prostate cancer cells based on in vitro and in vivo studies.
Dr. Gnanasekar Munirathinam
Guest Editor
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Keywords
- prostate cancer
- androgen receptor
- AR-V7
- castration-resistant prostate cancer
- dietary alkaloids
- dietary antioxidants
- phenolic compounds
- terpenoids
- phytochemicals
- xanthones
- probiotics
- preclinical
- marine bioactive agents
- molecular target
- signaling pathways
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