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Microbial Biofilms in Host Immune Responses and Antimicrobial Therapy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1929

Special Issue Editor


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Guest Editor
School of Science, Engineering and Environment, University of Salford, Manchester M5 4WT, UK
Interests: biofilms; immune response; antimicrobial resistance; host interactions

Special Issue Information

Dear Colleagues,

Various microorganisms often gravitate towards solid surfaces where they form biofilms as a strategy to protect themselves from environmental challenges and external toxic factors.

In this Special Issue, we invite papers from a broad range of disciplines focusing on microbial biofilms. In particular, we welcome research on host immune responses, antimicrobial therapy in animals and humans, and the behaviour of biofilms in different clinical settings. Our aim is to investigate the diversity in biofilm formation and biofilm–host interactions, and to identify disruption strategies that can be applied in different disciplines.

Dr. Mayri Alejandra Díaz De Rienzo
Guest Editor

Manuscript Submission Information

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Keywords

  • biofilms
  • immune response
  • antimicrobial resistance
  • disruption
  • quorum sensing
  • host interactions

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Published Papers (1 paper)

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Research

18 pages, 4787 KiB  
Article
Antimicrobial Surfaces: Stainless Steel Functionalized with the Essential Oil Component Vanillin
by Serena Medaglia, Ángela Morellá-Aucejo, María Ruiz-Rico, Félix Sancenón, Luis A. Villaescusa, Ramón Martínez-Máñez, M. Dolores Marcos and Andrea Bernardos
Int. J. Mol. Sci. 2024, 25(22), 12146; https://doi.org/10.3390/ijms252212146 - 12 Nov 2024
Cited by 3 | Viewed by 1584
Abstract
Pathogenic microorganisms can adhere to solid surfaces, leading to the formation of biofilms, thus building a physical barrier hindering the penetration and diffusion of antimicrobial compounds. In this context, the use of natural antimicrobial compounds, such as essential oil components, as substitutes for [...] Read more.
Pathogenic microorganisms can adhere to solid surfaces, leading to the formation of biofilms, thus building a physical barrier hindering the penetration and diffusion of antimicrobial compounds. In this context, the use of natural antimicrobial compounds, such as essential oil components, as substitutes for common synthetic antimicrobials in the fight to prevent antimicrobial resistance is explored. As stainless steel is one of the most widely used surfaces in different industries, we have developed an innovative antimicrobial treatment for stainless steel surfaces based on a multi-step functionalization process, in which the stainless steel surface is coated with a silica layer to which a vanillin derivative is covalently attached. The surface was analyzed by microscopy studies, indicating the correct immobilization on the surfaces. Antimicrobial studies (viability and bacterial adhesion assays) were performed against the bacteria Staphylococcus epidermidis, which is one of the most frequent causes of nosocomial infections. The results of the microbiological studies showed that vanillin-functionalized stainless steel surfaces reduce the bacteria viability by 100% and the biofilm formation on the stainless steel surface by 75% compared with non-functionalized surfaces, highlighting the contact-killing and adhesion resistance properties of the developed surface. Additional cycles using the functionalized surfaces showed good maintenance of the antimicrobial coating efficacy. Moreover, the surfaces coated with an intermediate silica layer demonstrated much greater antimicrobial activity than surfaces in which the active molecule was directly functionalized on the stainless steel surface. Full article
(This article belongs to the Special Issue Microbial Biofilms in Host Immune Responses and Antimicrobial Therapy)
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