Interaction between Gut Microbiome and Mucosal Immunity in the Gastrointestinal Disorders

Dear Colleagues,

This section aims enable rapid publication of contributions on all aspects of molecular pathology. Not only experimental studies but also translational research and clinical trials are acceptable. Clinical trials/data only are not acceptable.

The gut microbiome plays a pivotal role in the pathophysiology of various gastrointestinal disorders. Indeed, dysbiosis is significantly involved in the pathophysiology of inflammatory bowel disease, functional gastrointestinal disorders, non-alcoholic steatohepatitis, and gastrointestinal cancers. However, it remains unclear how the gut microbiome plays a crucial role in the pathophysiology of those diseases. To clarify this issue, the interaction between gut microbiome and mucosal immunity is certainly a key phenomenon, and the disruption of mucosal barrier function is integrally involved in such an interaction as a cause and/or a result. On the other hand, various factors including antibiotics, psychological stress or diet are known to alter not only the gut microbiome profile but also mucosal barrier function, inducing mucosal immune system activation and gastrointestinal minimal inflammation. In these contexts, this Special Issue aims to collect original research and review articles concerning new insights into the interaction between gut microbiome and gastrointestinal immune system in the gastrointestinal disorders, focusing its associated factors (antibiotics, psychological stress or diet, etc.) and resultant gastrointestinal minimal inflammation.

Dr. Hirokazu Fukui
Dr. Toshihiko Tomita
Guest Editors

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