Inflammation in Neurodegeneration

Dear Colleagues,

There is no doubt that pro-inflammatory immune-mediated mechanisms are pivotal to the pathogenicity and progression of neurodegenerative disorders. In this Special Issue, we would like to highlight the binary role of microglia activation in the pathophysiology of neurodegeneration, both neuroprotective and neuromodulatory. Additionally, we would like to show how the expression of several cytokines implicated in neurons’ degeneration could be used as a biomarker for several disorders.

Viral infections have been studied and correlated to neurodegenerative disorders’ progression, usually operating as trigger factors for the inflammatory process. The gut–brain axis and the possible contribution of peripheral bowel inflammation to neuronal death seems to be main contributors of brain neuroinflammation.  

We would also like to discuss therapeutic approaches concerning neurodegeneration and neuroinflammation, which have been studied in experimental and in vitro models and data stemming from epidemiological studies

Prof. Dr. Georgia Xiromerisiou
Guest Editor

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