Exposing Therapeutic Vulnerabilities in Cancer through Bioinformatics

Dear Colleagues,

Modern advances in genomic technologies have led to effective therapies against tumors with specific mutations. However, in a majority of cases, identifications of genomic alterations that dictate the fate of tumors and can be effectively targeted remain elusive. Additionally, while current immunotherapy-based approaches—such as immune checkpoint-blockade therapies—have resulted in improved survival in many patients, these therapies have significant liabilities due to the unpredictability of patient response and their high toxicity. This Special Issue of IJMS will discuss pathway/systems biology approaches aimed at the identification of tumor vulnerabilities to targeted or immune-based therapy. Topics include but are not limited to approaches that:

• Predict tumor response/resistance to standard of care drugs;
• Identify effective combinatorial therapies;
• Predict the effectiveness of alternative approaches such as fasting or ascorbic acid therapy;
• Develop immunograms that predict patient response to immune-based therapies;
• Predict individualized based toxicity in standard of care therapies.

Dr. Farhad Kosari
Guest Editor

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