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Special Issue "Growth Hormone Axis and Stress Biology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 31 March 2022.

Special Issue Editor

Dr. James M. Harper
E-Mail Website
Guest Editor
Department of Biological Sciences, Sam Houston State University, Huntsville, TX, USA
Interests: aging; endocrinology; comparative physiology; animal models; cell biology

Special Issue Information

Dear Colleagues,

Stress is a broad term that can refer to the adrenal response to noxious stimuli, both physiological and psychological, metabolic perturbances such as nutrient imbalances or exogenous insults such as toxins.  Importantly, the somatotropic and HPA axes often converge on pathways involved in mitigating the response to stress, regardless of the root cause, as well as having a significant degree of crosstalk to modulate each other’s activities. The Special Issue “Growth Hormone Axis and Stress” of the International Journal of Molecular Sciences will provide an overview of the role of GH signaling in modulating the response to stress through a series of original research articles and reviews. 

Topics include:

  • GH/IGF axis and HPA axis activity
  • Glucocorticoids and somatotrope function
  • Diet, GH, and POMC activity
  • Ghrelin and stress related behaviors
  • GH and Nrf2 activity
  • GH and stress resistance pituitary mutants
  • GH and oxidative stress
  • GH and ER stress
  • Stress, GH, and muscle function
  • Glucocorticoids and IGF-I signaling
  • Stress and obesity
  • Social stress and GH signaling

Dr. James M. Harper
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Glucocorticoids
  • Cortisol
  • Corticosterone
  • Cortistatin
  • Adrenocorticotropic hormone
  • Growth Hormone
  • Insulin-like growth factor-I
  • Ghrelin
  • HPA axis
  • Somatotropic axis
  • Stress
  • Oxidative stress
  • ER Stress
  • Metabolic Stress
  • Cytotoxic stress

Published Papers (1 paper)

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Research

Article
Effects of Growth Hormone Receptor Ablation in Corticotropin-Releasing Hormone Cells
Int. J. Mol. Sci. 2021, 22(18), 9908; https://doi.org/10.3390/ijms22189908 - 14 Sep 2021
Viewed by 300
Abstract
Corticotropin-releasing hormone (CRH) cells are the dominant neuronal population responsive to the growth hormone (GH) in the paraventricular nucleus of the hypothalamus (PVH). However, the physiological importance of GH receptor (GHR) signaling in CRH neurons is currently unknown. Thus, the main objective of [...] Read more.
Corticotropin-releasing hormone (CRH) cells are the dominant neuronal population responsive to the growth hormone (GH) in the paraventricular nucleus of the hypothalamus (PVH). However, the physiological importance of GH receptor (GHR) signaling in CRH neurons is currently unknown. Thus, the main objective of the present study was to investigate the consequences of GHR ablation in CRH-expressing cells of male and female mice. GHR ablation in CRH cells did not cause significant changes in body weight, body composition, food intake, substrate oxidation, locomotor activity, glucose tolerance, insulin sensitivity, counterregulatory response to 2-deoxy-D-glucose and ghrelin-induced food intake. However, reduced energy expenditure was observed in female mice carrying GHR ablation in CRH cells. The absence of GHR in CRH cells did not affect anxiety, circadian glucocorticoid levels or restraint-stress-induced corticosterone secretion and activation of PVH neurons in both male and female mice. In summary, GHR ablation, specifically in CRH-expressing neurons, does not lead to major alterations in metabolism, hypothalamic–pituitary–adrenal axis, acute stress response or anxiety in mice. Considering the previous studies showing that central GHR signaling regulates homeostasis in situations of metabolic stress, future studies are still necessary to identify the potential physiological importance of GH action on CRH neurons. Full article
(This article belongs to the Special Issue Growth Hormone Axis and Stress Biology)
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