Genomics and Epigenetics of Stem Cell
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (10 July 2023) | Viewed by 6933
Special Issue Editors
Interests: cell biology; cell technology; oncology; orthopaedics; molecular biology
Special Issues, Collections and Topics in MDPI journals
Interests: medicine; transfusion medicine; immunohaematology; immunogenetics; immune disorders of erythrocytes, thrombocytes and granulocytes; molecular diagnostics of genetic traits on the blood cells; transplantation of blood forming tissue; haematopoietic stem cells; immunotherapy of cancer
Special Issue Information
Dear Colleagues,
Stem cells are the focus of extensive research and medical applications. Acquiring knowledge of their epigenetic changes, which can influence upregulation and downregulation of the cell genome, is important to describe the mechanisms and function of stem cells. Proper differentiation in one of more than 200 different cell types in the human body is essential for safe and effective applications in regenerative medicine. The sequencing of the genome alone did not yield the expected results, and the real cell physiology work started after that accumulated knowledge from information provided by NGS. Changes in chromatin structure influence the expression of the genes, epigenetic changes being one of the most important mechanisms. Epigenetics play key roles in development, stem cell differentiation, and have a high impact on human disease, and they occur throughout life from embryonic development into adulthood. Stem cells undergo several cellular divisions in a regulated manner; the genetic code remains the same in theory, but several mutations or other phenomena related to aging can cause changes in phenotypes. The information is particularly essential for strategies of cell-based therapies, where pure populations of required cell types are required for transplantation. Epigenetic changes related with aging play a critical role in quality of stem cells and their differentiated daughter cells, as well as the functioning of regenerated tissues, organs, organ systems and, finally, the whole body.
This Special Issue of the International Journal of Molecular Sciences focuses on the research field of “Genomics and Epigenetics of Stem Cell” and welcomes both original research articles and review papers.
Dr. Miomir Knezevic
Dr. Primoz Rozman
Guest Editors
Manuscript Submission Information
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Keywords
- regenerative medicine
- cell expansion
- gene therapy
- tissue engineering
- tumour vaccines
- immunotherapy of cancer
- autoimmune diseases
- stem cell biology
- cell cryopreservation
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