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Volume 24
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Review

The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells

by
Li Ma
,
Xuguang He
and
Qiang Wu
*
The State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau 999078, China
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2023, 24(16), 12909; https://doi.org/10.3390/ijms241612909
Submission received: 23 July 2023 / Revised: 6 August 2023 / Accepted: 10 August 2023 / Published: 18 August 2023
(This article belongs to the Special Issue Genomics and Epigenetics of Stem Cell)
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Abstract

Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) are isolated from Wharton’s jelly tissue of umbilical cords. They possess the ability to differentiate into lineage cells of three germ layers. WJ-MSCs have robust proliferative ability and strong immune modulation capacity. They can be easily collected and there are no ethical problems associated with their use. Therefore, WJ-MSCs have great tissue engineering value and clinical application prospects. The identity and functions of WJ-MSCs are regulated by multiple interrelated regulatory mechanisms, including transcriptional regulation and epigenetic modifications. In this article, we summarize the latest research progress on the genetic/epigenetic regulation mechanisms and essential signaling pathways that play crucial roles in pluripotency and differentiation of WJ-MSCs.
Keywords: WJ-MSCs; transcriptional regulation; epigenetic modifications; signaling pathways; differentiation WJ-MSCs; transcriptional regulation; epigenetic modifications; signaling pathways; differentiation

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MDPI and ACS Style

Ma, L.; He, X.; Wu, Q. The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells. Int. J. Mol. Sci. 2023, 24, 12909. https://doi.org/10.3390/ijms241612909

AMA Style

Ma L, He X, Wu Q. The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells. International Journal of Molecular Sciences. 2023; 24(16):12909. https://doi.org/10.3390/ijms241612909

Chicago/Turabian Style

Ma, Li, Xuguang He, and Qiang Wu. 2023. "The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells" International Journal of Molecular Sciences 24, no. 16: 12909. https://doi.org/10.3390/ijms241612909

APA Style

Ma, L., He, X., & Wu, Q. (2023). The Molecular Regulatory Mechanism in Multipotency and Differentiation of Wharton’s Jelly Stem Cells. International Journal of Molecular Sciences, 24(16), 12909. https://doi.org/10.3390/ijms241612909

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