Mitochondrial Biology: Novel Insights and Frontier Discoveries
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 October 2024) | Viewed by 193
Special Issue Editor
Interests: mitochondrial transport; energy metabolism; L-and D-lactate transport and metabolism in animal, plant, yeast, and cancer mitochondria; light-biological systems interactions; programmed cell death
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Special Issue Information
Dear Colleagues,
Although mitochondrial biology in mammalian, plant and yeast systems has been investigated since the beginning of the last century, some aspects remain obscure and not well-understood. Indeed, more recently, attention has been paid to the role of mitochondria in a variety of physio-pathological situations, including mitochondrial disfunction, cancer, microbiota–mitochondria inter-talk, apoptosis, etc. Moreover, much research has been carried ou under experimental conditions which can hardly be considered as physiological, being essentially devoted to ascertaining the substrate–protein–lipid interactions at molecular level in reconstituted systems. On the other hand, some enzymes, considered present only in the cytoplasm, have recently been localized in the mitochondrial compartments. Finally, how mitochondria can obtain some molecules needed for their function, such as vitamins and vitamin derivatives, remain rather obscure.
Therefore, we consider that the study of the role of mitochondria in major metabolic pathways, including glycolysis (lactate mitochondrial transport and metabolism, mitochondrial shuttles), gluconeogenesis (L-lactate and Cori cycle, D-lactate transport and metabolism, glutamine as a precursor of glucose, etc.), urea cycle (fumarate fate), fatty acid synthesis (the role of phosphoenolpyruvate and mitochondrial pyruvate kinase, etc.) and the mechanism by which mitochondria obtain their enzymes, merits further investigation and/or revision.
Prof. Dr. Salvatore Passarella
Guest Editor
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Keywords
- mitochondrial biology
- mitochondrial disfunction
- glycolysis
- gluconeogenesis
- urea cycle
- fatty acid synthesis
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