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Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Physical Chemistry and Chemical Physics".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 11040

Special Issue Editor

Prof. Anatoly F. Vanin

E-Mail Website
Guest Editor
Semenov Federal Research Center of Chemical Physics Russian Academy of Sciences Kosygin Str.4, 939991 Moscow, Russia
Interests: dinitrosyl iron complexes (DNIC); nitric oxide; S-nitrosothiols; electron paramagnetic resonance(EPR) biological application

Special Issue Information

Dear Colleagues,

Dinitrosyl iron complexes (DNIC) with thiol-containing ligands are found in almost all living organisms when nitric oxide (NO), being a universal regulator of biological processes, and its various endogenous derivatives appear in them.

The following factors allow us to consider DNIC as the “working form” of NO: DNIC’s ability to donate neutral NO molecules and nitrosonium cations NO+, these complexes fully imitate NO biological activity, and this agent is mainly included in cells and tissues in DNIC.

The purpose of the proposed issue is to overview the latest analytical evidence on physical and chemical properties DNIC with thiol-containing ligands determining the biological activity of these complexes as NO and NO+ donors. This analysis can be useful for better understanding the mechanisms of regulatory and cytotoxic action of endogenous NO in living organisms, and for developing novel drugs with a similar effect on a human and animal organisms.

Prof. Anatoly F. Vanin
Guest Editor

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Keywords

  • dinitrosyl iron copmplex
  • nitric oxide
  • S-nitrosothiols

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Published Papers (3 papers)

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Research

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18 pages, 1739 KiB  
Article
Protective Effect of Dinitrosyl Iron Complexes Bound with Hemoglobin on Oxidative Modification by Peroxynitrite
by Olga V. Kosmachevskaya, Elvira I. Nasybullina, Konstantin B. Shumaev, Natalia N. Novikova and Alexey F. Topunov
Int. J. Mol. Sci. 2021, 22(24), 13649; https://doi.org/10.3390/ijms222413649 - 20 Dec 2021
Cited by 14 | Viewed by 2411
Abstract
Dinitrosyl iron complexes (DNICs) are a physiological form of nitric oxide (•NO) in an organism. They are able not only to deposit and transport •NO, but are also to act as antioxidant and antiradical agents. However, the mechanics of hemoglobin-bound [...] Read more.
Dinitrosyl iron complexes (DNICs) are a physiological form of nitric oxide (•NO) in an organism. They are able not only to deposit and transport •NO, but are also to act as antioxidant and antiradical agents. However, the mechanics of hemoglobin-bound DNICs (Hb-DNICs) protecting Hb against peroxynitrite-caused, mediated oxidative modification have not yet been scrutinized. Through EPR spectroscopy we show that Hb-DNICs are destroyed under the peroxynitrite action in a dose-dependent manner. At the same time, DNICs inhibit the oxidation of tryptophan and tyrosine residues and formation of carbonyl derivatives. They also prevent the formation of covalent crosslinks between Hb subunits and degradation of a heme group. These effects can arise from the oxoferryl heme form being reduced, and they can be connected with the ability of DNICs to directly intercept peroxynitrite and free radicals, which emerge due to its homolysis. These data show that DNICs may ensure protection from myocardial ischemia. Full article
(This article belongs to the Special Issue Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity)
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18 pages, 7007 KiB  
Article
Cell-Penetrating Delivery of Nitric Oxide by Biocompatible Dinitrosyl Iron Complex and Its Dermato-Physiological Implications
by Yu-Chieh Chen, Yi-Hong Chen, Han Chiu, Yi-Hsuan Ko, Ruei-Ting Wang, Wei-Ping Wang, Yung-Jen Chuang, Chieh-Cheng Huang and Tsai-Te Lu
Int. J. Mol. Sci. 2021, 22(18), 10101; https://doi.org/10.3390/ijms221810101 - 18 Sep 2021
Cited by 20 | Viewed by 4412
Abstract
After the discovery of endogenous dinitrosyl iron complexes (DNICs) as a potential biological equivalent of nitric oxide (NO), bioinorganic engineering of [Fe(NO)2] unit has emerged to develop biomimetic DNICs [(NO)2Fe(L)2] as a chemical biology tool for controlled [...] Read more.
After the discovery of endogenous dinitrosyl iron complexes (DNICs) as a potential biological equivalent of nitric oxide (NO), bioinorganic engineering of [Fe(NO)2] unit has emerged to develop biomimetic DNICs [(NO)2Fe(L)2] as a chemical biology tool for controlled delivery of NO. For example, water-soluble DNIC [Fe2(μ-SCH2CH2OH)2(NO)4] (DNIC-1) was explored for oral delivery of NO to the brain and for the activation of hippocampal neurogenesis. However, the kinetics and mechanism for cellular uptake and intracellular release of NO, as well as the biocompatibility of synthetic DNICs, remain elusive. Prompted by the potential application of NO to dermato-physiological regulations, in this study, cellular uptake and intracellular delivery of DNIC [Fe2(μ-SCH2CH2COOH)2(NO)4] (DNIC-2) and its regulatory effect/biocompatibility toward epidermal cells were investigated. Upon the treatment of DNIC-2 to human fibroblast cells, cellular uptake of DNIC-2 followed by transformation into protein-bound DNICs occur to trigger the intracellular release of NO with a half-life of 1.8 ± 0.2 h. As opposed to the burst release of extracellular NO from diethylamine NONOate (DEANO), the cell-penetrating nature of DNIC-2 rationalizes its overwhelming efficacy for intracellular delivery of NO. Moreover, NO-delivery DNIC-2 can regulate cell proliferation, accelerate wound healing, and enhance the deposition of collagen in human fibroblast cells. Based on the in vitro and in vivo biocompatibility evaluation, biocompatible DNIC-2 holds the potential to be a novel active ingredient for skincare products. Full article
(This article belongs to the Special Issue Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity)
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Review

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35 pages, 7030 KiB  
Review
Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity
by Anatoly F. Vanin
Int. J. Mol. Sci. 2021, 22(19), 10356; https://doi.org/10.3390/ijms221910356 - 26 Sep 2021
Cited by 35 | Viewed by 3306
Abstract
In this article we minutely discuss the so-called “oxidative” mechanism of mononuclear form of dinitrosyl iron complexes (M-DNICs) formations proposed by the author. M-DNICs are proposed to be formed from their building material—neutral NO molecules, Fe2+ ions and anionic non-thiol (L− [...] Read more.
In this article we minutely discuss the so-called “oxidative” mechanism of mononuclear form of dinitrosyl iron complexes (M-DNICs) formations proposed by the author. M-DNICs are proposed to be formed from their building material—neutral NO molecules, Fe2+ ions and anionic non-thiol (L−) and thiol (RS−) ligands based on the disproportionation reaction of NO molecules binding with divalent ion irons in pairs. Then a protonated form of nitroxyl anion (NO−) appearing in the reaction is released from this group and a neutral NO molecule is included instead. As a result, M-DNICs are produced. Their resonance structure is described as [(L−)2Fe2+(NO)(NO+)], in which nitrosyl ligands are represented by NO molecules and nitrosonium cations in equal proportions. Binding of hydroxyl ions with the latter causes conversion of these cations into nitrite anions at neutral pH values and therefore transformation of DNICs into the corresponding high-spin mononitrosyl iron complexes (MNICs) with the resonance structure described as [(L−)2Fe2+(NO)]. In case of replacing L− by thiol-containing ligands, which are characterized by high π-donor activity, electron density transferred from sulfur atoms to iron-dinitrosyl groups neutralizes the positive charge on nitrosonium cations, which prevents their hydrolysis, ensuring relatively a high stability of the corresponding M-DNICs with the resonance structure [(RS−)2Fe2+ (NO, NO+)]. Therefore, M-DNICs with thiol-containing ligands, as well as their binuclear analogs (B-DNICs, respective resonance structure [(RS−)2Fe2+2 (NO, NO+)2]), can serve donors of both NO and NO+. Experiments with solutions of B-DNICs with glutathione or N-acetyl-L-cysteine (B-DNIC-GSH or B-DNIC-NAC) showed that these complexes release both NO and NO+ in case of decomposition in the presence of acid or after oxidation of thiol-containing ligands in them. The level of released NO was measured via optical absorption intensity of NO in the gaseous phase, while the number of released nitrosonium cations was determined based on their inclusion in S-nitrosothiols or their conversion into nitrite anions. Biomedical research showed the ability of DNICs with thiol-containing ligands to be donors of NO and NO+ and produce various biological effects on living organisms. At the same time, NO molecules released from DNICs usually have a positive and regulatory effect on organisms, while nitrosonium cations have a negative and cytotoxic effect. Full article
(This article belongs to the Special Issue Physico-Chemistry of Dinitrosyl Iron Complexes as a Determinant of Their Biological Activity)
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