The Methylome as an Emerging Profiler of Exposome
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 3605
Special Issue Editor
Special Issue Information
Dear Colleagues,
Decades of investigations on the causal role of the environment in human disease and morbidity led to the conception of "exposome". It refers to the totality of the exposures suffered by an individual, that comes from all sources, (i.e. environment, food, psychosocial components, endogenous exposure), in a life-course perspective from the womb onwards. One of the key tools for the development and application of the exposome concept is the use of global sets of biomarkers (-omics) as generic measures of the internal exposome and disease risk. Among them, alterations in epigenetic biomarkers such as DNA methylation have been associated with various exposures, and in many cases proved to be critical determinants of disease risk and aetiology. In addition, the long-lasting nature of their fingerprint (methylome) is a prerequisite for the temporal component of the exposome. Therefore, deviations on CpG methylation or hydroxymethylation could function as the biological mediators between the environmental exposures and their effect on health and thus bridge the gap between the genetic and environmental determinants of human diseases. This Special Issue in the International Journal of Molecular Sciences entitled "The methylome as an emerging profiler of exposome" invites studies, reviews, and commentaries related to this emerging area of environmental epigenetics.
Dr. Panagiotis Georgiadis
Guest Editor
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Keywords
- Exposome
- Methylation
- Hydroxymethylation
- Exposure
- environment
- epigenetics
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