Oxidative Stress and Inflammation in Cardiovascular Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 7200
Special Issue Editor
Interests: cardiovascular toxicology; calcium homeostasis; clinical pharmacology; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cardiovascular disease is one of the major healthcare problems worldwide. Growing bodies of evidences indicate that oxidative stress and inflammation are intricately linked mechanisms and are significant drivers in the development and progression of cardiovascular disease. Indeed, both oxidative stress and inflammation are enhanced in chronic heart failure and are also involved in drug induced-cardiotoxicity. Oxidative stress also causes myocardial tissue damage and inflammation, contributing to heart failure progression, while a subclinical inflammatory state may be caused by heart failure comorbidities such as obesity or diabetes mellitus. The close interaction of inflammation with oxidative stress is corroborated by clinical data reporting an aggravated inflammatory phenotype in the absence of antioxidant defense proteins (e.g., superoxide dismutases, heme oxygenase-1, and glutathione peroxidases) or overexpression of reactive oxygen species producing enzymes (e.g., NADPH oxidases) and a normalization of oxidative stress exerted by antiinflammatory drugs in cardiovascular diseases.
This Special Issue is calling both original articles and reviews providing to the readers of IJMS a comprehensive, deep understanding of our current knowledge on oxidative stress and inflammation in cardiovascular diseases.
Dr. Ada Popolo
Guest Editor
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Keywords
- oxidative stress
- inflammation
- cardiovascular disease
- cardiotoxicity
- endothelial dysfunction
- mitochondrial stress
- antiinflammatory and antioxidant drug discovery
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