Advances in Molecular Biology of Pituitary Diseases

Dear Colleagues,

This Special Issue aims to present the latest research on the molecular biology of pituitary diseases. Pituitary adenoma is a common disease, accounting for about 10% of the general population, and generally presents as a benign tumor. However, in rare cases, tumors can become malignant and metastasize. Pituitary adenomas are also associated with specific syndromes (e.g., acromegaly, Cushing’s syndrome, prolactinoma, syndrome of inappropriate TSH secretion) due to inappropriate hormone secretion. Continuous advances in molecular biology techniques have improved our understanding of the pathogenesis and biology of these tumors, and this knowledge can be applied to the development of diagnostic methods and treatment options. Interestingly, molecular biology techniques have uncovered the pathophysiological mechanisms of non-neoplastic pituitary diseases, such as thyroid hormone resistance syndrome or inappropriate non-neoplastic TSH secretion. An important topic regarding syndromes of reduced thyroid hormone sensitivity is the discovery of polymorphisms in gene encoding type 2 deiodinase. Finally, genetic analysis can identify mutations in genes encoding transcription factors involved in pituitary development that may be involved in the pathogenesis of pituitary hormone deficiency.

Dr. Rosa Maria Paragliola
Prof. Dr. Salvatore Maria Corsello
Guest Editors

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• pituitary adenomas
• pituitary carcinomas
• hypopituitarism
• acromegaly
• somatostatin receptor ligands
• prolactinoma
• Cushing’s syndrome
• TSH-secreting adenomas
• syndromes of reduced sensitivity to thyroid hormones