Journal Browser

Journal Browser

Lipid Signaling and Metabolism in Inflammation-Associated Diseases 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 678

Special Issue Editor

E-Mail Website
Guest Editor
Department of Biochemistry, Charité – University Medicine Berlin, Charitéplatz 1, CCO-Building, Virchowweg 6, D-10117 Berlin, Germany
Interests: lipid metabolism; catalytic mechanism; eicosanoids; lipoxygenase; leukotrienes; selenocysteine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is a continuation of our previous Special Issue "Lipid Signaling and Metabolism in Inflammation-Associated Diseases".

When the human body is challenged by pathogens, cell damage or irritants, a complex counteracting response of the immune system is initiated. This response is aimed at eliminating the inflammatory stimuli and at re-establishing tissue homeostasis. Although the inflammatory response is beneficial for the entire body, it involves locally destructive processes leading to cell injury and tissue damage. During the phase of inflammatory resolution (healing phase), the inflamed tissue is cleaned up and the original tissue structure is reestablished. In principle, inflammation can affect all organs, and can thus impact organ-specific functions. However, despite tissue-specific differences, the basic mechanisms are always similar. In most cases, inflammation starts as an acute process which either heals completely (restitution ad integrum) or turns into chronic inflammation when the healing process is incomplete. A key event in acute inflammation is the local activation of immune cells, particularly of neutrophils and pro-inflammatory M1 macrophages. Lymphocytes (B- and T-cells) are rare in acutely inflamed tissue, but occur more frequently in chronic inflammation. Inflammatory cells are attracted by pro-inflammatory signals produced in inflamed tissue. They leave the vasculature and actively migrate towards the center of inflammation following the gradient of pro-inflammatory mediators. Acute inflammation and inflammatory resolution are characterized by specific profiles of lipid mediators, which are biosynthesized by different cell types. It is the aim of this Special Issue to summarize our current knowledge on lipid signaling and lipid metabolism in all types of inflammation-associated diseases, which includes the biosynthesis and modes of action of pro- and anti-inflammatory lipid mediators.

Prof. Dr. Hartmut Kühn
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • prostaglandins
  • leukotrienes
  • lipoxins
  • resolvins/maresins
  • hepoxilins
  • eoxins
  • cyclooxygenas
  • lipoxygenase
  • cytochrome P450

Related Special Issue

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


15 pages, 1916 KiB  
Harnessing Oxylipins and Inflammation Modulation for Prevention and Treatment of Colorectal Cancer
by Julius Gretschel, Racha El Hage, Ruirui Wang, Yifang Chen, Anne Pietzner, Andreas Loew, Can G. Leineweber, Jonas Wördemann, Nadine Rohwer, Karsten H. Weylandt and Christoph Schmöcker
Int. J. Mol. Sci. 2024, 25(10), 5408; https://doi.org/10.3390/ijms25105408 - 15 May 2024
Viewed by 413
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, ranking as the third most malignant. The incidence of CRC has been increasing with time, and it is reported that Westernized diet and lifestyle play a significant role in its higher incidence [...] Read more.
Colorectal cancer (CRC) is one of the most prevalent cancers worldwide, ranking as the third most malignant. The incidence of CRC has been increasing with time, and it is reported that Westernized diet and lifestyle play a significant role in its higher incidence and rapid progression. The intake of high amounts of omega-6 (n − 6) PUFAs and low levels of omega-3 (n − 3) PUFAs has an important role in chronic inflammation and cancer progression, which could be associated with the increase in CRC prevalence. Oxylipins generated from PUFAs are bioactive lipid mediators and have various functions, especially in inflammation and proliferation. Carcinogenesis is often a consequence of chronic inflammation, and evidence has shown the particular involvement of n − 6 PUFA arachidonic acid-derived oxylipins in CRC, which is further described in this review. A deeper understanding of the role and metabolism of PUFAs by their modifying enzymes, their pathways, and the corresponding oxylipins may allow us to identify new approaches to employ oxylipin-associated immunomodulation to enhance immunotherapy in cancer. This paper summarizes oxylipins identified in the context of the initiation, development, and metastasis of CRC. We further explore CRC chemo-prevention strategies that involve oxylipins as potential therapeutics. Full article
Show Figures

Figure 1

Back to TopTop