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Bioactive Molecules in Oral-Related Health Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 4209

Special Issue Editor


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Guest Editor
1. Department of Biomaterials and Bioengineering, INSERM UMR_S 1121, Strasbourg University, 67000 Strasbourg, France
2. Department of Endodontics, Faculty of Dental Medicine, Strasbourg University, 67000 Strasbourg, France
3. Pôle de Médecine et Chirurgie Bucco-Dentaire, Hôpital Civil, Hôpitaux Universitaire de Strasbourg, 67000 Strasbourg, France
Interests: endodontics-cariology; prosthetic therapeutics on implants; biological material–tissue interfaces
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Special Issue Information

Dear Colleague,

Several molecules have many applications in the dental field. Diverse types of natural and synthetic molecules are used for oral treatment. These molecules are used in a broad range of applications related to dental pulp treatment, surgical procedures, bone management, implantology, periodontics, conservative and endodontic treatment, orthodontics, and prosthodontics. Moreover, in recent years, Bioactive materials have become available for dental purposes. The aim of this Special Issue is to provide the latest information on dental bioactive materials and molecules used in the oral environment. Original articles describing in vitro and in vivo research and reviews are all welcome.

This Special Issue is supervised by Prof. Dr. Youssef Haïkel and assisted by our Topical Advisory Panel Members Dr. Naji Kharouf  (Strasbourg University). and Dr. Davide Mancino (Strasbourg University). This Special Issue addresses the role of bioactive molecules in the treatment of the oral cavity including, in soft and hard tissues. Original research articles on these and related topics are welcome, including comprehensive reviews.

Prof. Dr. Youssef Haïkel
Guest Editor

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Keywords

  • dental biomaterials
  • medical devices
  • bioactive materials
  • dental surgery
  • restorative dentistry
  • rehabilitation of oral environment
  • oral cavity diseases

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Published Papers (1 paper)

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Research

22 pages, 6919 KiB  
Article
Titanium Particles Modulate Lymphocyte and Macrophage Polarization in Peri-Implant Gingival Tissues
by Waad Kheder, Amal Bouzid, Thenmozhi Venkatachalam, Iman M. Talaat, Noha Mousaad Elemam, Tom Kalathil Raju, Soumya Sheela, Manju Nidagodu Jayakumar, Azzam A. Maghazachi, Abdul Rani Samsudin and Rifat Hamoudi
Int. J. Mol. Sci. 2023, 24(14), 11644; https://doi.org/10.3390/ijms241411644 - 19 Jul 2023
Cited by 16 | Viewed by 3481
Abstract
Titanium dental implants are one of the modalities to replace missing teeth. The release of titanium particles from the implant’s surface may modulate the immune cells, resulting in implant failure. However, little is known about the immune microenvironment that plays a role in [...] Read more.
Titanium dental implants are one of the modalities to replace missing teeth. The release of titanium particles from the implant’s surface may modulate the immune cells, resulting in implant failure. However, little is known about the immune microenvironment that plays a role in peri-implant inflammation as a consequence of titanium particles. In this study, the peri-implant gingival tissues were collected from patients with failed implants, successful implants and no implants, and then a whole transcriptome analysis was performed. The gene set enrichment analysis confirmed that macrophage M1/M2 polarization and lymphocyte proliferation were differentially expressed between the study groups. The functional clustering and pathway analysis of the differentially expressed genes between the failed implants and successful implants versus no implants revealed that the immune response pathways were the most common in both comparisons, implying the critical role of infiltrating immune cells in the peri-implant tissues. The H&E and IHC staining confirmed the presence of titanium particles and immune cells in the tissue samples, with an increase in the infiltration of lymphocytes and macrophages in the failed implant samples. The in vitro validation showed a significant increase in the level of IL-1β, IL-8 and IL-18 expression by macrophages. Our findings showed evidence that titanium particles modulate lymphocyte and macrophage polarization in peri-implant gingival tissues, which can help in the understanding of the imbalance in osteoblast–osteoclast activity and failure of dental implant osseointegration. Full article
(This article belongs to the Special Issue Bioactive Molecules in Oral-Related Health Applications)
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