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Biology and Pathology of the Human Hair Follicle

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 1738

Special Issue Editor


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Guest Editor
1. Dr Phillip Frost Dept. of Dermatology & Cutaneous Surgery, University of Miami Miller School of of Medicine, Miami, FL, USA
2. Monasterium Laboratory, Münster, Germany
3. CUTANEON – Skin & Hair Inventions, Hamburg, Germany
4. Centre for Dermatology Research, University of Manchester, Manchester, UK
Interests: hair follicle; hair; skin; keratinocyte

Special Issue Information

Dear Colleagues, 

While the most fundamental progress in basic hair biology over the past few decades has arguably been made by studying mutant mouse models, translating this into advances in the clinical management of hair growth or hair pigmentation disorders has been disappointingly slow. In part, this results from the fact that there are substantial but often underestimated or ignored differences between murine and human hair follicles (HFs), their growth controls, and their response to pharmacological intervention, which must be taken into account when extrapolating from mouse-based concepts to the human condition. The current Special Issue will therefore assemble a much-needed compendium of human HF biology that not only synthesizes the essence of what is currently known about human HF physiology and key controls of human hair growth, pigmentation, and HF stem cells, but also pinpoint how human and mouse HFs differ. This is complemented by presenting key principles of human HF pathobiology, by discussing key open questions in translational human hair research, and by delineating preclinical assays that are best suited to answer these.

Prof. Dr. Ralf Paus
Guest Editor

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Published Papers (1 paper)

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Research

8 pages, 1873 KiB  
Communication
Investigation of Glypican-4 and -6 by Infrared Spectral Imaging during the Hair Growth Cycle
by Charlie Colin-Pierre, Valérie Untereiner, Ganesh D. Sockalingum, Laurent Ramont and Stéphane Brézillon
Int. J. Mol. Sci. 2023, 24(5), 4291; https://doi.org/10.3390/ijms24054291 - 21 Feb 2023
Viewed by 1403
Abstract
The expression of glypicans in different hair follicle (HF) compartments is still poorly understood. Heparan sulfate proteoglycans (HSPGs) distribution in HF is classically investigated by conventional histology, biochemical analysis, and immunohistochemistry. Our previous study proposed a novel approach to assess hair histology and [...] Read more.
The expression of glypicans in different hair follicle (HF) compartments is still poorly understood. Heparan sulfate proteoglycans (HSPGs) distribution in HF is classically investigated by conventional histology, biochemical analysis, and immunohistochemistry. Our previous study proposed a novel approach to assess hair histology and glypican-1 (GPC1) distribution changes in the HF at different phases of the hair growth cycle using infrared spectral imaging (IRSI). We show in the present manuscript for the first time complementary data on the distribution of glypican-4 (GPC4) and glypican-6 (GPC6) in HF at different phases of the hair growth cycle using IR imaging. Findings were supported by Western blot assays focusing on the GPC4 and GPC6 expression in HFs. Like all proteoglycan features, the glypicans are characterized by a core protein to which sulfated and/or unsulfated glycosaminoglycan (GAG) chains are covalently linked. Our study demonstrates the capacity of IRSI to identify the different HF tissue structures and to highlight protein, proteoglycan (PG), GAG, and sulfated GAG distribution in these structures. The comparison between anagen, catagen, and telogen phases shows the qualitative and/or quantitative evolution of GAGs, as supported by Western blot. Thus, in one analysis, IRSI can simultaneously reveal the location of proteins, PGs, GAGs and sulfated GAGs in HFs in a chemical and label-free manner. From a dermatological point of view, IRSI may constitute a promising technique to study alopecia. Full article
(This article belongs to the Special Issue Biology and Pathology of the Human Hair Follicle)
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