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Bioactive Tissue Repair and Regeneration: Focus on Endodontics
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Bioactive Tissue Repair and Regeneration: Focus on Endodontics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 14111

Special Issue Editors

Dr. Maxime Ducret

E-Mail Website
Guest Editor
1. Institut de Biologie et Chimie des Protéines, Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305 CNRS, Université Claude Bernard Lyon 1, 69367 Lyon, France
2. Pôle d’Odontologie, Hospices Civils de Lyon, 69008 Lyon, France
Interests: tissue engineering; tissue repair and regeneration; biomaterials; dental pulp; digital dentistry
Dr. Mourad Bekhouche

E-Mail Website
Guest Editor
Laboratoire de Génétique et Biologie Cellulaire, UVSQ, Université Paris-Saclay, 78000 Versailles, France
Interests: tissue repair and regeneration; matrix biology; dental pulp
Prof. Dr. Jean-Christophe Farges

E-Mail Website
Guest Editor
1. Institut de Biologie et Chimie des Protéines, Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305 CNRS, Université Claude Bernard Lyon 1, 69367 Lyon, France
2. Pôle d’Odontologie, Hospices Civils de Lyon, 69008 Lyon, France
Interests: dental pulp; tissue repair and regeneration; inflammation; immune response

Special Issue Information

Dear Colleagues,

Current endodontic treatments of the tooth are based on the use of inactive synthetic materials. This statement is clearly insufficient and faces criticism due to the loss of tooth vitality, with the absence of the regenerative and immune capacities of dental pulp.

Recently, numerous alternative strategies were investigated to maintain or restore tooth vitality and functions. These approaches based on tissue engineering and regenerative medicine use advanced molecular cues and specifically designed materials to promote DP repair and regeneration. However, many challenging questions remain to be investigated, including the choice of stem-cell-based or cell-free strategies, the promotion of the bioactive properties of cells and the selection of materials able to achieve a true regeneration of the dental pulp. This complex regenerative mechanism is also complicated by the presence of remaining bacteria and biofilms, which make endodontic repair and regeneration a complex strategy. Even if most of these approaches are currently at different levels of maturity, they all help to better understand and drive the molecular and cellular mechanisms that promote the regeneration of a functional tissue as opposed to the anarchic structure that was previously reported.

This Special Issue aims to report the cutting-edge advances in this field of tissue repair and regeneration applied to endodontics. Innovative studies and reviews in the field of bioactive endodontic materials, with or without stem cells, scaffolds and/or cues are welcomed. Investigations of dental pulp regeneration at a cellular or molecular level will be also considered, as long as they contribute to the transfer of this knowledge from the bench to bedside.

Dr. Maxime Ducret
Dr. Mourad Bekhouche
Prof. Dr. Jean-Christophe Farges
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dental pulp
  • tissue engineering
  • biomaterials
  • stem cells
  • bioactivity
  • revitalization
  • inflammation

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Published Papers (3 papers)

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Research

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19 pages, 20293 KB  
Article
Silver Nanoparticles Alone or in Combination with Calcium Hydroxide Modulate the Viability, Attachment, Migration, and Osteogenic Differentiation of Human Mesenchymal Stem Cells
by Almaha S. Algazlan, Nihal Almuraikhi, Manikandan Muthurangan, Hanan Balto and Fahd Alsalleeh
Int. J. Mol. Sci. 2023, 24(1), 702; https://doi.org/10.3390/ijms24010702 - 31 Dec 2022
Cited by 19 | Viewed by 3225
Abstract
This study aimed to evaluate the effect of silver nanoparticles (AgNPs) alone or in combination with calcium hydroxide (Ca(OH)2) on the proliferation, viability, attachment, migration, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Different concentrations of AgNPs alone or mixed [...] Read more.
This study aimed to evaluate the effect of silver nanoparticles (AgNPs) alone or in combination with calcium hydroxide (Ca(OH)2) on the proliferation, viability, attachment, migration, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Different concentrations of AgNPs alone or mixed with Ca(OH)2 were prepared. Cell proliferation was measured using AlamarBlue, and hMSCs attachment to dentin disks was evaluated using scanning electron microscopy. Live–dead imaging was performed to assess apoptosis. Wound healing ability was determined using the scratch-migration assay. To evaluate osteogenic differentiation, the expression of Runt-related transcription factor (RUNX2), Transforming growth factor beta-1 (TGF-β1), Alkaline Phosphatase (ALP), and Osteocalcin (OCN) were measured using real-time reverse transcriptase polymerase chain reaction. ALP staining and activity were also performed as indicators of osteogenic differentiation. AgNPs alone seemed to favor cell attachment. Lower concentrations of AgNPs enhanced cell proliferation. AgNP groups showed markedly less apoptosis. None of the medicaments had adverse effects on wound closure. The expression of TGF-β1 was significantly upregulated in all groups, and OCN was highly expressed in the AgNP groups. AgNPs 0.06% showed the most enhanced ALP gene expression levels, activity, and marked cytochemical staining. In conclusion, AgNPs positively affect hMSCs, making them a potential biomaterial for various clinical applications. Full article
(This article belongs to the Special Issue Bioactive Tissue Repair and Regeneration: Focus on Endodontics)
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Review

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12 pages, 1412 KB  
Review
Bioactive Endodontic Hydrogels: From Parameters to Personalized Medicine
by Marianne Leveque, Mourad Bekhouche, Jean-Christophe Farges, Audrey Aussel, Kadiatou Sy, Raphaël Richert and Maxime Ducret
Int. J. Mol. Sci. 2023, 24(18), 14056; https://doi.org/10.3390/ijms241814056 - 13 Sep 2023
Cited by 10 | Viewed by 2786
Abstract
Regenerative endodontic procedures (REPs) aim at recreating dental pulp tissue using biomaterials such as hydrogels. Their bioactivity is mostly related to the nature of biomolecules or chemical compounds that compose the endodontic hydrogel. However, many other parameters, such as hydrogel concentration, bioactive molecules [...] Read more.
Regenerative endodontic procedures (REPs) aim at recreating dental pulp tissue using biomaterials such as hydrogels. Their bioactivity is mostly related to the nature of biomolecules or chemical compounds that compose the endodontic hydrogel. However, many other parameters, such as hydrogel concentration, bioactive molecules solubility, and apex size, were reported to influence the reciprocal host–biomaterial relationship and hydrogel behavior. The lack of knowledge regarding these various parameters, which should be considered, leads to the inability to predict the clinical outcome and suggests that the biological activity of endodontic hydrogel is impossible to anticipate and could hinder the bench-to-bedside transition. We describe, in this review, that most of these parameters could be identified, described, and studied. A second part of the review lists some challenges and perspectives, including development of future mathematical models that are able to explain, and eventually predict, the bioactivity of endodontic hydrogel used in a clinical setting. Full article
(This article belongs to the Special Issue Bioactive Tissue Repair and Regeneration: Focus on Endodontics)
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29 pages, 1746 KB  
Review
Neural Regeneration in Regenerative Endodontic Treatment: An Overview and Current Trends
by Yali Wei, Ping Lyu, Ruiye Bi, Xinyu Chen, Yanshen Yu, Zucen Li and Yi Fan
Int. J. Mol. Sci. 2022, 23(24), 15492; https://doi.org/10.3390/ijms232415492 - 7 Dec 2022
Cited by 25 | Viewed by 7306
Abstract
Pulpal and periapical diseases are the most common dental diseases. The traditional treatment is root canal therapy, which achieves satisfactory therapeutic outcomes—especially for mature permanent teeth. Apexification, pulpotomy, and pulp revascularization are common techniques used for immature permanent teeth to accelerate the development [...] Read more.
Pulpal and periapical diseases are the most common dental diseases. The traditional treatment is root canal therapy, which achieves satisfactory therapeutic outcomes—especially for mature permanent teeth. Apexification, pulpotomy, and pulp revascularization are common techniques used for immature permanent teeth to accelerate the development of the root. However, there are obstacles to achieving functional pulp regeneration. Recently, two methods have been proposed based on tissue engineering: stem cell transplantation, and cell homing. One of the goals of functional pulp regeneration is to achieve innervation. Nerves play a vital role in dentin formation, nutrition, sensation, and defense in the pulp. Successful neural regeneration faces tough challenges in both animal studies and clinical trials. Investigation of the regeneration and repair of the nerves in the pulp has become a serious undertaking. In this review, we summarize the current understanding of the key stem cells, signaling molecules, and biomaterials that could promote neural regeneration as part of pulp regeneration. We also discuss the challenges in preclinical or clinical neural regeneration applications to guide deep research in the future. Full article
(This article belongs to the Special Issue Bioactive Tissue Repair and Regeneration: Focus on Endodontics)
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