Bioactive Tissue Repair and Regeneration: Focus on Endodontics

Dear Colleagues,

Current endodontic treatments of the tooth are based on the use of inactive synthetic materials. This statement is clearly insufficient and faces criticism due to the loss of tooth vitality, with the absence of the regenerative and immune capacities of dental pulp.

Recently, numerous alternative strategies were investigated to maintain or restore tooth vitality and functions. These approaches based on tissue engineering and regenerative medicine use advanced molecular cues and specifically designed materials to promote DP repair and regeneration. However, many challenging questions remain to be investigated, including the choice of stem-cell-based or cell-free strategies, the promotion of the bioactive properties of cells and the selection of materials able to achieve a true regeneration of the dental pulp. This complex regenerative mechanism is also complicated by the presence of remaining bacteria and biofilms, which make endodontic repair and regeneration a complex strategy. Even if most of these approaches are currently at different levels of maturity, they all help to better understand and drive the molecular and cellular mechanisms that promote the regeneration of a functional tissue as opposed to the anarchic structure that was previously reported.

This Special Issue aims to report the cutting-edge advances in this field of tissue repair and regeneration applied to endodontics. Innovative studies and reviews in the field of bioactive endodontic materials, with or without stem cells, scaffolds and/or cues are welcomed. Investigations of dental pulp regeneration at a cellular or molecular level will be also considered, as long as they contribute to the transfer of this knowledge from the bench to bedside.

Dr. Maxime Ducret
Dr. Mourad Bekhouche
Prof. Dr. Jean-Christophe Farges
Guest Editors

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