Novel Antibacterial Drugs: Discovery, Synthesis and Design
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4537
Special Issue Editor
Interests: amphibians; peptide chemistry; antimicrobial peptides; peptide synthesis; peptide analogues; neurotoxic peptides; scorpions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Random mutations cause genetic variations in microorganisms, so the emergence of antimicrobial resistance is a natural evolutionary process; however, external selective pressures, such as exposure to antimicrobial agents in healthcare, agriculture, and the environment, can accelerate the dissemination of these genes. Antimicrobial resistance threatens, at alarming levels, the limited treatment options available and portends one of the greatest global public health crises. There are already reports of pathogens endowed with resistance to multiple drugs (MDR) that are considered untreatable, a particularly worrying situation in the context of nosocomial infections and one that has worsened during the COVID-19 pandemic, due to the significant increase in the use of antibiotics during this period. The scenario of resistance has been shaped by a combination of factors, such as the inappropriate use of antibiotics in clinical practice and the livestock industry, the use of bactericides and fungicides in agriculture, and even environmental pollution. This situation becomes especially urgent when one notices the lack of new antibiotics under development. The latest discovery of a new antibiotic class that has reached the market was back in 1987, showing a large gap in the evolution of antimicrobial therapies, which remains until today. In view of this situation, the search for new antibacterial compounds becomes urgent, and this Special Issue will accept original research articles and reviews that highlight the discovery, synthesis, and design of novel antibacterial agents, essential initiatives through which to limit the dissemination of multidrug-resistant microorganisms and ensure the adequate treatment of exposed populations, preventing associated human losses.
Prof. Dr. Mariana S. Castro
Guest Editor
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Keywords
- antibacterial agents
- bacterial infections
- discovery
- rational design
- small molecules
- peptides
- peptidomimetics
- antibacterial drug targets
- structure–activity relationship
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