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Molecular Research on Tumor Metastasis and Inhibition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 September 2025 | Viewed by 942

Special Issue Editor

Special Issue Information

Dear Colleagues,

We are proposing a Special Issue on “Molecular Research on Tumor Metastasis and Inhibition”.

Cancer metastasis is one of the hallmarks of cancer. It is a symbol and an important event for tumor cells. In this process, tumor cells use their abilities to migrate/invade, and some cells may undergo morphological changes. At the same time, the secretion of matrix metalloproteinase, changes in the cytoskeleton, and destruction of the basement membrane will follow. At this stage, the overall microenvironment becomes hypoxic, acidic, and angiogenic. Therefore, based on the above, tumor metastasis represents an advanced stage of cancer progression with a poor survival rate, and more effective drugs and treatment options are urgently needed.

This Special Issue of IJMS aims to bring together a range of original research articles and reviews. Our focus is on pan-cancer, covering the diagnosis, treatment, and prognosis of metastatic events. Research on biomarker discovery, 'omic' approaches (such as genomics, proteomics, genomics, and transcriptomics), and many other areas is welcome. We also welcome the use of cells, animal models, and clinical specimens to study cancer metastasis events and the use of clinical regimens in combination with potential compounds/herbal drugs, peptides, or non-coding RNA to counteract their consequences. We expect these topics to improve current cancer treatments and to be at the forefront of drug development.

Dr. Yu-Chan Chang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metastasis
  • epithelial–mesenchymal transition
  • small-molecule compounds
  • animal imaging
  • signal transduction

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Published Papers (1 paper)

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Review

15 pages, 506 KiB  
Review
Role of Soluble Cytokine Receptors in Gastric Cancer Development and Chemoresistance
by Francesca Lospinoso Severini, Geppino Falco and Tiziana Notarangelo
Int. J. Mol. Sci. 2025, 26(6), 2534; https://doi.org/10.3390/ijms26062534 - 12 Mar 2025
Viewed by 614
Abstract
Gastric cancer is among the top five most important malignancies in the world due to the high burden of the disease and its lethality. Indeed, it is the fourth most common cause of death worldwide, characterized by a poor prognosis and low responsiveness [...] Read more.
Gastric cancer is among the top five most important malignancies in the world due to the high burden of the disease and its lethality. Indeed, it is the fourth most common cause of death worldwide, characterized by a poor prognosis and low responsiveness to chemotherapy. Multidrug resistance limits the clinical management of the patient. Among these, the role of chronic activation of inflammatory pathways underlying gastric tumorigenesis should be highlighted. Furthermore, the gastric immunosuppressive TME influences the response to therapy. This review discusses the role of soluble cytokine receptors in the development and chemoresistance of gastric cancer, considered as a molecular marker and target of strategies to overcome resistance. Full article
(This article belongs to the Special Issue Molecular Research on Tumor Metastasis and Inhibition)
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