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Advances in Nanoparticle-Based Therapeutics
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Advances in Nanoparticle-Based Therapeutics

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (31 March 2023) | Viewed by 3349

Special Issue Editor

Dr. Moshi Geso

E-Mail Website
Guest Editor
Discipline of Medical Radiations, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia
Interests: nanoparticles; radiation; radiotherapy; radiology; dose; radio-sensitisation; ionising radiations; theranostic; radiobiology; non-ionising radiation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Novel functional nanomaterials have become a new research hotspot in the field of medical treatment strategies. Its outstanding advantages are increasingly valued by the medical community, especially in the field of cancer and inflammation treatment. The combination of nanotechnology and biomedicine has provided a new way of thinking for the medical community. The properties of nanoparticles, such as small diameter, large specific surface area, and sensitivity to the surrounding environment, enable them to play a targeted role in tumor imaging and therapy. Using nanomaterials as drug delivery systems can also improve the absorption and utilization of drugs, achieve efficient targeted delivery, prolong drug half-life, and reduce toxic side effects to normal tissues.

This special issue aims to collect relevant research on nanoparticle-based therapy, including but not limited to the following topics:

  • Nano Biomedical Materials;
  • Nanoparticle photothermal therapy;
  • Novel Nano-drug Delivery System;
  • Applications of Magnetic Nanoparticles.

Dr. Moshi Geso
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoparticle
  • gold nanoparticles
  • nanoparticle-based photothermal therapy
  • magnetic nanoparticles
  • biomimetic nano-drug carrier system

Published Papers (2 papers)

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Research

15 pages, 2340 KiB  
Article
Comparative Study of Nanoparticle Blood Circulation after Forced Clearance of Own Erythrocytes (Mononuclear Phagocyte System-Cytoblockade) or Administration of Cytotoxic Doxorubicin- or Clodronate-Loaded Liposomes
by Elizaveta N. Mochalova, Elena A. Egorova, Kristina S. Komarova, Victoria O. Shipunova, Nelli F. Khabibullina, Petr I. Nikitin and Maxim P. Nikitin
Int. J. Mol. Sci. 2023, 24(13), 10623; https://doi.org/10.3390/ijms241310623 - 25 Jun 2023
Cited by 3 | Viewed by 1530
Abstract
Recent developments in the field of nanomedicine have introduced a wide variety of nanomaterials that are capable of recognizing and killing tumor cells with increased specificity. A major limitation preventing the widespread introduction of nanomaterials into the clinical setting is their fast clearance [...] Read more.
Recent developments in the field of nanomedicine have introduced a wide variety of nanomaterials that are capable of recognizing and killing tumor cells with increased specificity. A major limitation preventing the widespread introduction of nanomaterials into the clinical setting is their fast clearance from the bloodstream via the mononuclear phagocyte system (MPS). One of the most promising methods used to overcome this limitation is the MPS-cytoblockade, which forces the MPS to intensify the clearance of erythrocytes by injecting allogeneic anti-erythrocyte antibodies and, thus, significantly prolongs the circulation of nanoagents in the blood. However, on the way to the clinical application of this approach, the question arises whether the induced suppression of macrophage phagocytosis via the MPS-cytoblockade could pose health risks. Here, we show that highly cytotoxic doxorubicin- or clodronate-loaded liposomes, which are widely used for cancer therapy and biomedical research, induce a similar increase in the nanoparticle blood circulation half-life in mice as the MPS-cytoblockade, which only gently and temporarily saturates the macrophages with the organism’s own erythrocytes. This result suggests that from the point of view of in vivo macrophage suppression, the MPS-cytoblockade should be less detrimental than the liposomal anti-cancer drugs that are already approved for clinical application while allowing for the substantial improvement in the nanoagent effectiveness. Full article
(This article belongs to the Special Issue Advances in Nanoparticle-Based Therapeutics)
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19 pages, 11257 KiB  
Article
Cell-Molecular Interactions of Nano- and Microparticles in Dental Implantology
by Varvara Labis, Ernest Bazikyan, Denis Demin, Irina Dyachkova, Denis Zolotov, Alexey Volkov, Victor Asadchikov, Olga Zhigalina, Dmitry Khmelenin, Daria Kuptsova, Svetlana Petrichuk, Elena Semikina, Svetlana Sizova, Vladimir Oleinikov, Sergey Khaidukov and Ivan Kozlov
Int. J. Mol. Sci. 2023, 24(3), 2267; https://doi.org/10.3390/ijms24032267 - 23 Jan 2023
Cited by 4 | Viewed by 1504
Abstract
The role of metallic nano- and microparticles in the development of inflammation has not yet been investigated. Soft tissue biopsy specimens of the bone bed taken during surgical revisions, as well as supernatants obtained from the surface of the orthopedic structures and dental [...] Read more.
The role of metallic nano- and microparticles in the development of inflammation has not yet been investigated. Soft tissue biopsy specimens of the bone bed taken during surgical revisions, as well as supernatants obtained from the surface of the orthopedic structures and dental implants (control), were examined. Investigations were performed using X-ray microtomography, X-ray fluorescence analysis, and scanning electron microscopy. Histological studies of the bone bed tissues were performed. Nanoscale and microscale metallic particles were identified as participants in the inflammatory process in tissues. Supernatants containing nanoscale particles were obtained from the surfaces of 20 units of new dental implants. Early and late apoptosis and necrosis of immunocompetent cells after co-culture and induction by lipopolysaccharide and human venous blood serum were studied in an experiment with staging on the THP-1 (human monocytic) cell line using visualizing cytometry. As a result, it was found that nano- and microparticles emitted from the surface of the oxide layer of medical devices impregnated soft tissue biopsy specimens. By using different methods to analyze the cell–molecule interactions of nano- and microparticles both from a clinical perspective and an experimental research perspective, the possibility of forming a chronic immunopathological endogenous inflammatory process with an autoimmune component in the tissues was revealed. Full article
(This article belongs to the Special Issue Advances in Nanoparticle-Based Therapeutics)
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