The Role of Glutathione Metabolism in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (25 June 2024) | Viewed by 3964
Special Issue Editor
Interests: colon cancer; gastric cancer; Notch signaling pathway; glutathione in cancer; antioxidant enzymes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Glutathione (GSH) is essential for several antioxidant processes and appears to be the most important non-enzymatic antioxidant in cells. For example, it acts as a regulator of the cellular redox state to protect cells from damage caused by lipid peroxides, reactive oxygen and nitrogen species, and xenobiotics. GSH has also been shown to participate in key signalling pathways and to regulate, e.g., proliferation or apoptosis. One of the most important roles of GSH is its involvement in the regeneration of enzymatic and non-enzymatic antioxidants. Cancer initiation, progression, and response to treatment have been linked to molecular alterations in the GSH antioxidant system and disruption of GSH homeostasis. It is also worth noting that in healthy cells it is essential for removing and detoxifying carcinogens, whereas elevated GSH levels in cancer cells have been linked to tumour progression and increased resistance to chemotherapeutic drugs.
Therefore, a better understanding of the role of GSH in health and diseases, including cancer, especially at the molecular level, may improve prognosis and treatment response. For this Special Issue, we invite manuscripts on the role of GSH (and enzymes which are connected with GSH activity) in healthy cells and pathological tissues.
Dr. Marlena Brzozowa-Zasada
Guest Editor
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Keywords
- glutathione metabolism
- glutathione activity
- cancer
- reactive oxygen species (ROS)
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