Research on Synthetic Medicinal Chemistry
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 90
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue, entitled "Research on Synthetic Medicinal Chemistry", aims to highlight the latest advances and innovative approaches in the field of medicinal chemistry. This Special Issue will focus on the exploration of drug development through synthetic chemistry and the intricate relationship between chemical structure and biological activity. Topics covered will include the following: the synthesis of new bioactive molecules for targeting undrugged proteins; lead optimization techniques; the creation and use of PROTACs and other degradation agents; and targeting nucleic acids with synthetic small molecules. Moreover, a particular interest will be reserved for the use of powerful technologies like DNA-encoded libraries and artificial intelligence (AI).
Researchers are invited to contribute original research articles, comprehensive reviews, and insightful short communications that address these critical areas. The goal is to showcase cutting-edge research that advances the understanding of synthetic medicinal chemistry, providing a platform for interdisciplinary collaboration and innovation. By bringing together contributions from leading scientists, this Special Issue aims to drive forward the discovery and development of new therapeutic solutions that can address pressing global health challenges. Potential contributors are invited to submit papers on the following topics:
- Synthesis of new bioactive molecules;
- Discovery of new scaffolds for targeting undrugged proteins;
- Novel synthetic methodologies for drug development;
- Structure–activity relationship (SAR) studies in medicinal chemistry;
- Development and application of PROTACs and other degraders;
- Targeting nucleic acids with synthetic small molecules.
Dr. Alberto Ongaro
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- drug development
- lead optimization
- degraders
- PROTACs
- bioactive molecules
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