Latest Review Papers in Biochemistry
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Editors
Prof. Dr. Cheng-Yang Huang
Prof. Dr. Cheng-Yang Huang
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1. Department of Biomedical Sciences, Chung Shan Medical University, Taichung City 402, Taiwan
2. Department of Medical Research, Chung Shan Medical University Hospital, Taichung City 402, Taiwan
Interests: plant extracts; natural products; enzyme inhibitors; molecular mechanisms
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Athanasios Salifoglou
Prof. Dr. Athanasios Salifoglou
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School of Chemical Engineering, Faculty of Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece
Interests: bioinorganic chemistry; molecular engineering; hybrid materials; metallodrugs; cell (patho)physiologies; neurodegeneration; neoplastic process
Special Issues, Collections and Topics in MDPI journals
Topical Collection Information
Dear Colleagues,
This Topical Collection aims to collect high-quality review papers across all fields of biochemistry. Biochemistry remains a cornerstone of the life sciences, bridging the fields of molecular biology, structural biology, enzymology, metabolism, and drug development. As experimental and computational technologies continue to advance rapidly, there is an increasing demand for timely and comprehensive review articles that synthesize recent discoveries and emerging concepts from diverse areas of biochemistry. We welcome review articles that summarize cutting-edge progress, explore unresolved questions, highlight new techniques or methodologies, and offer forward-looking perspectives in the field. Topics of interest of this Special Issue include but are not limited to the following: enzyme structure, function, and regulation; protein–protein and protein–ligand interactions; metabolic and signaling pathways; nucleic acid chemistry and RNA biology; biochemical mechanisms of disease; redox biology and oxidative stress; molecular docking and computational modeling; biochemical approaches in drug discovery; synthetic and systems biochemistry; emerging biotechnological applications of biochemistry. We also strongly encourage contributions reviewing the biological activities of bioactive constituents derived from plant extracts.
Prof. Dr. Cheng-Yang Huang
Prof. Dr. Athanasios Salifoglou
Collection Editors
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Keywords
- enzyme function
- protein-ligand interaction
- structure
- mechanism
- biomolecule
- signaling pathway
- nucleic acid chemistry
- redox biology
- drug discovery
- natural product
Published Papers (1 paper)
2025
Open AccessReview
The Involvement of Ceramide, Sphingosine-1-Phosphate and Ganglioside GM1 in Regulating Some Nervous System Functions
by
Paola Giussani, Laura Mauri and Sandro Sonnino
Viewed by 758
Abstract
Sphingolipids are a large group of molecules, crucial components of all mammalian cells, that are particularly abundant in the central and peripheral nervous system and associated with important human brain functions. Sphingolipids are necessary for membrane organization and driving functions. Ceramide, sphingosine-1-phosphate and
[...] Read more.
Sphingolipids are a large group of molecules, crucial components of all mammalian cells, that are particularly abundant in the central and peripheral nervous system and associated with important human brain functions. Sphingolipids are necessary for membrane organization and driving functions. Ceramide, sphingosine-1-phosphate and GM1, show bioactive properties. Ceramide and sphingosine-1-phosphate play a crucial role in the regulation of physio-pathological conditions. Small changes in their levels, in the ratio sphingosine-1-phosphate/ceramide as well as in chain length profiles of sphingolipids contribute to alter signaling pathways in neurons and glia, contributing to various neurological disorders. GM1 is considered a neurotrophic and neuroprotective compound and seems to be necessary for the correct functioning of neuronal membrane receptors, suggesting that a reduction in its level in the brain can be involved in neurodegenerative diseases. In this review, we give an overview of sphingolipid metabolism, summarizing the role of ceramide, sphingosine-1-phosphate, and GM1 in maintaining human health.
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