Nanoparticles in Inhaled Drug Delivery
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 3528
Special Issue Editor
Interests: inhaled drug delivery; nanotechnology; natural/synthetic polymeric nanoparticles; lung delivery of anticancer drugs; nanoparticulate lung drug delivery against lower respiratory tract infections
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Drug delivery directly into the lungs is an efficient method to achieve both local and systemic effects for therapeutic agents. The advantages of pulmonary drug delivery include superior efficacy, low toxicity, and sustained and rapid onset of action, which other drug administration routes (except injections) cannot achieve. The large epithelial surface area, extremely thin absorptive alveolar epithelial membrane, and good blood supply are notable factors that make the lung an ideal drug delivery route for the treatment of both local and systemic disorders. Delivery of drugs into the lungs ensures low systemic side-effects compared with oral or intravenous administration and no first-pass metabolism, which is a common problem for orally administered drugs.
The use of nanoparticulate drugs has been found to resolve various challenges in drug delivery, especially to cancer cells. This includes a preferential accumulation of the nanoparticles into the cancer cells, extending the half-lives of drugs in the circulation and reducing unwanted adverse effects in non-target organs. Nanoparticulate delivery of many anticancer drugs has been reported with significant success. Inhaled nanoparticles of various antibacterial drugs prepared using a variety of natural and synthetic polymers have been investigated for lung infections. Nanoparticles of the polymer–drug conjugate, polymer-encapsulated drug, solid lipid nanoparticles, and drug-loaded liposomes are very commonly used nanomedicines targeted for lung delivery. Respiratory tract infections, especially lower respiratory tract infections (LRTIs), are a leading cause of death and morbidity globally. There is an urgent need to develop effective new antibiotic delivery approaches in respiratory tract infections that allow accurate targeting of pathogens with enhanced bacterial killing, especially resistant bacteria without off-target adverse effects.
The Special Issue of the International Journal of Molecular Sciences entitled “Nanoparticles in Inhaled Drug Delivery” focuses on the studies of inhaled nanoparticulate drugs for the management of various diseases.
In this Special Issue, original research articles and critical reviews are welcome.
Dr. Nazrul Islam
Guest Editor
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Keywords
- inhaled nanoparticles
- inhaled antibacterial formulations and delivery
- inhaled anticancer drugs
- polymeric drug nanoparticles for lung delivery
- controlled release of inhalable antibacterial/anticancer drugs and their toxicity
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