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New Research on Anti-Inflammatory Molecules in Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 769

Special Issue Editors


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Guest Editor
Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Naples, Italy
Interests: sex differences in inflammatory diseases and implications for sex-related therapy; pathobiochemistry of inflammation; molecular and biochemical pharmacology of natural and synthetic anti-inflammatory molecules
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Guest Editor
Department of Pharmacy, University of Naples Federico II, 80138 Naples, Italy
Interests: airway function; inflammatory lung diseases; sphingolipid metabolism; lipid mediators
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammatory diseases are the most common acute and chronic health conditions in the world. They are characterized by a very complex pathophysiological process, involving a myriad of enzymes, mediators, and receptors, producing proinflammatory and anti-inflammatory molecules. Despite the fact that the discovery of anti-inflammatory drugs has been very extensive, inflammatory diseases remain among the most serious health burdens, and the medical need for more potent and safe anti-inflammatory drugs still remains.

The topics covered will include (but are not limited to) the following:

  • The individuation of new targets for anti-inflammatory therapy;
  • Natural products as novel therapeutic strategies in inflammatory diseases;
  • New synthetic compounds with anti-inflammatory proprieties.

Prof. Dr. Antonietta Rossi
Prof. Dr. Fiorentina Roviezzo
Guest Editors

Manuscript Submission Information

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Keywords

inflammation

anti-inflammatory molecules

natural products

lipid mediators

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Published Papers (2 papers)

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Research

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17 pages, 2096 KiB  
Article
Long-Term Real-World Effectiveness of Dupilumab vs. Upadacitinib in Early Treatment Responders with Atopic Dermatitis: Results from Central European Health Fund Registry
by Katarzyna Waligóra-Dziwak, Aleksandra Dańczak-Pazdrowska and Dorota Jenerowicz
Int. J. Mol. Sci. 2025, 26(9), 4230; https://doi.org/10.3390/ijms26094230 - 29 Apr 2025
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Abstract
While clinical trials have shown the efficacy of using dupilumab and upadacitinib to treat atopic dermatitis (AD), long-term real-world data remain limited. This retrospective cohort study, utilizing data from the Polish National Health Fund Registry, evaluates the long-term effectiveness of dupilumab versus upadacitinib [...] Read more.
While clinical trials have shown the efficacy of using dupilumab and upadacitinib to treat atopic dermatitis (AD), long-term real-world data remain limited. This retrospective cohort study, utilizing data from the Polish National Health Fund Registry, evaluates the long-term effectiveness of dupilumab versus upadacitinib in early treatment responders, focusing on sustained efficacy outcomes and high levels of skin clearance. Data from the Polish National Health Fund Registry were analyzed for 435 patients; 220 were treated with dupilumab and 215 were treated with upadacitinib, each receiving treatment for at least 40 weeks. Upadacitinib had a faster onset of action, leading to significantly higher rates of complete skin clearance compared to dupilumab at weeks 16 and 28 (EASI100 at week 16: 19.5% vs. 7.3%, p < 0.001; week 28: 26.5% vs. 12.7%, p < 0.001). Dupilumab showed continuous efficacy gains, ultimately demonstrating superiority in achieving EASI75 and EASI90 at week 40, though no significant difference was observed in achieving EASI100. Both treatments provided sustained dermatological improvement and enhanced quality of life, achieving high levels of skin clearance over the long term. Full article
(This article belongs to the Special Issue New Research on Anti-Inflammatory Molecules in Diseases)
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Review

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22 pages, 965 KiB  
Review
Integrating Proteomics into Personalized Medicine for Inflammatory Bowel Disease—Reality or Challenge?
by Horia Minea, Ana-Maria Singeap, Manuela Minea, Simona Juncu, Stefan Andrei Chiriac, Catalin Victor Sfarti, Carol Stanciu and Anca Trifan
Int. J. Mol. Sci. 2025, 26(11), 4993; https://doi.org/10.3390/ijms26114993 - 22 May 2025
Abstract
Inflammatory bowel diseases (IBD) represent chronic conditions with etiopathogenic mechanisms incompletely elucidated despite extensive research efforts. Therefore, it is essential for clinical monitoring of the implementation of personalized medicine, enabling risk stratification and the selection of therapies with the highest likelihood of a [...] Read more.
Inflammatory bowel diseases (IBD) represent chronic conditions with etiopathogenic mechanisms incompletely elucidated despite extensive research efforts. Therefore, it is essential for clinical monitoring of the implementation of personalized medicine, enabling risk stratification and the selection of therapies with the highest likelihood of a favorable response. Multi-omics approaches have emerged as an excellent opportunity for the prevention, clinical phenotype differentiation, and prediction of IBD development. Proteomics has gained significant enthusiasm in medical practice, primarily due to its focus on studying the composition and dynamic expression of various cellular and tissue structures. This approach provides critical insights into their impact on signaling pathways, post-translational modifications, and the development of sequence variations. Hence, it could provide the foundation for developing biomarkers with the potential to assess mucosal healing and predict prognostic variability among patients, facilitating the implementation of a personalized therapeutic approach. This review focuses on the recent research regarding the possibility of implementing proteomics technologies into clinical practice, given the challenges and limitations, and the advantages of increasing the quality of life in patients with IBD. Full article
(This article belongs to the Special Issue New Research on Anti-Inflammatory Molecules in Diseases)
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