Molecular Research in Allergic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 20301
Special Issue Editors
Interests: airway function; inflammatory lung diseases; sphingolipid metabolism; lipid mediators
Special Issues, Collections and Topics in MDPI journals
Interests: sex differences in inflammatory diseases and implications for sex-related therapy; pathobiochemistry of inflammation; molecular and biochemical pharmacology of natural and synthetic anti-inflammatory molecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear colleagues,
Over the last years bioactive lipids have emerged as clinically-relevant mediators of allergic disease pathophysiology. Compelling evidence suggests the importance of lipid mediators in the development of asthma, allergic rhinitis, atopic dermatitis, anaphylaxis, and food allergy. Lipids play key roles in cell signaling events, influencing physiologic (bronchial tone) and immune mechanisms (degranulation, chemotaxis, and sensitization) in allergic diseases. Lipids act through several cellular mechanisms such as the formation of structural support platforms (lipid rafts) for receptor signaling complexes, the activation of a diverse family of G-protein coupled receptors, and the mediation of intracellular signaling cascades by acting as second messengers. An increased understanding of these critical bioactive molecules will drive future innovations in treating atopy in its many forms. This Special Issue aims to shed light on and further the understanding of some of these intricate signaling mechanisms in allergic diseases. Specifically, we propose to explore and discuss the following points: (1) lipid synthesis pathways and signaling in atopic disease pathology; (2) the development of allergic disease treatments targeting lipid mediator pathways
Prof. Fiorentina Roviezzo
Dr. Antonietta Rossi
Guest Editors
Manuscript Submission Information
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Keywords
- atopy
- asthma
- immune inflammation
- sphingolipid
- leukotrienes
- anaphylaxis
- therapeutic targets
- food allergy
