Novel Approaches to Preventing and Alleviating Metabolic Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 791
Special Issue Editor
Interests: lipid metabolism; metabolic disorder of post-menopausal women; free radical research; diabetes; obesity; sexual hormonal changes; metabolomics; nutritional genetics; multi omics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Whether men or women, various metabolic changes tend to occur after the age of 50 due to hormonal changes. Especially in women, hormonal changes, such as decreased levels of estrogen and increased levels of circulating androgens, can lead to the development of cardiovascular disease and metabolic syndrome, including type 2 diabetes. In women, estrogen deficiency can lead to a chronic inflammatory state, including increased proinflammatory cytokines, impaired Treg/Th17 cell balance, and impaired osteogenic differentiation capacity of bone marrow mesenchymal stem cells (BMSCs). Inadequate bone formation by BMSC-derived osteoblasts to compensate for bone resorption by osteoblasts is a major cause of osteoporosis in postmenopausal women. In men, a decrease in androgens and an increase in estrogen accelerate muscle loss and decrease basal metabolic rate, increasing the risk of abdominal obesity.
Metabolic syndrome is defined as a group of disorders characterized by impaired glucose metabolism, hypertension, central obesity, low LDL-C, and high triglyceride levels. It also promotes a chronic systemic inflammatory state characterized by glucose intolerance and immune cell infiltration, and this immune system activation increases the risk of serious illness following viral infection. Additionally, studies have been reported on the increase in diseases related to various metabolic diseases such as non-alcoholic fatty liver disease, psoriasis, and inflammatory bowel disease. Metabolic diseases tend to progress quietly and gradually rather than showing acute symptoms.
There is an urgent need for molecular biological research that can prevent and alleviate metabolic diseases caused by hormonal changes that naturally occur with aging.
We request the cooperation of fellow researchers to maintain a better quality of life.
Dr. Seong-Hee Maria Ko
Guest Editor
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Keywords
- metabolic diseases
- metabolic syndrome
- glucose metabolism
- hypertension
- obesity
- non-alcoholic fatty liver disease
- psoriasis
- inflammatory bowel disease
- molecular biological research
- hormonal change
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