Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review
Abstract
1. Introduction
2. Results
2.1. Study Selection
2.2. Characteristics of the Included Studies
2.3. Endodontic Procedures
2.3.1. Pulpotomy and Pulp Capping
2.3.2. Regenerative Endodontic Procedures in Immature Teeth
2.3.3. Apexification
2.3.4. Apical Surgery
2.3.5. Reimplantation of Avulsed Tooth and Intentional Reimplantation
2.3.6. Autotransplantation
2.3.7. Biological Effects
2.3.8. Endo-Perio Lesions
2.3.9. Root Fracture
2.3.10. Management of Root Perforation
2.3.11. Mechanical Properties
2.3.12. Management of Root Resorption
2.3.13. Regeneration of Mature Teeth
3. Discussion
4. Materials and Methods
4.1. Protocol Registration
4.2. Review Questions
4.3. Information Sources
4.4. Search Strategy
4.5. Eligibility Criteria
4.6. Selection Process
4.7. Data Extraction
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Conflicts of Interest
Abbreviations
A-PRF | Advanced platelet-rich fibrin |
CGF | Concentrated growth factors |
IGF-1 | Insulin-like growth factor 1 |
IGF-2 | Insulin-like growth factor 2 |
I-PRF | Injectable platelet-rich fibrin |
IL-1 | Interleukin-1 |
IL-4 | Interleukin-4 |
IL-6 | Interleukin-6 |
L-PRF | Leucocyte platelet-rich fibrin |
MeSH | Medical subject headings |
MTA | Mineral trioxide aggregate |
OSF | Open science framework |
P-PRP | Pure platelet-rich plasma |
PCC | Population, concept, context |
PDGF | Platelet-derived growth factor |
PRF | Platelet-rich fibrin |
PRISMA-ScR | Preferred reporting items for systematic reviews and meta-analysis protocols, Scoping review extension guidelines |
PRP | Platelet-rich plasma |
RCT | Randomized controlled trial |
RET | Regenerative endodontic treatment |
RPM | Revolution per minute |
T-PRF | Titanium platelet-rich fibrin |
TGF-B1 | Transforming growth factor B1 |
VEGF | Vascular endothelial growth factor |
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n | % | |
---|---|---|
STUDY TYPE | ||
Case report | 93 | 22.52% |
Narrative review | 66 | 13.98% |
Randomized controlled trial | 62 | 15.01% |
Randomized controlled trial protocol | 52 | 12.59% |
Systematic review | 42 | 10.17% |
Animal | 34 | 8.23% |
Case-series | 27 | 6.54% |
In vitro | 24 | 5.81% |
Cohort | 5 | 1.21% |
Case-control | 3 | 0.73% |
Scoping review | 3 | 0.73% |
Umbrella review | 2 | 0.48% |
Total (Studies) | 413 | 100% |
TYPE OF PROCEDURE | ||
Regeneration of immature teeth | 185 | 44.90% |
Apical surgery | 80 | 19.42% |
Pulpotomy/Pulp capping | 56 | 13.59% |
Regeneration of mature teeth | 39 | 9.47% |
Biological properties evaluation | 38 | 9.22% |
Apexification | 20 | 4.85% |
Endo-perio lesions | 16 | 3.88% |
Intentional reimplantation | 13 | 3.16% |
Perforation | 10 | 2.43% |
Resorption | 5 | 1.21% |
Root fracture | 3 | 0.73% |
Auto transplant | 2 | 0.49% |
Mechanical properties evaluation | 2 | 0.49% |
Total (Articles) | 412 | 100% |
TOP 10 JOURNALS | ||
Journal of Endodontics | 55 | 13.35% |
International Endodontic Journal | 20 | 4.85% |
Journal of Conservative Dentistry | 19 | 4.61% |
Journal of Clinical and Diagnostic Research | 17 | 3.13% |
Contemporary Clinical Dentistry | 10 | 2.43% |
International Journal of Pediatric Dentistry | 8 | 1.94% |
Restorative Dentistry and Endodontics | 8 | 1.94% |
The Journal of Contemporary Dental Practice | 7 | 1.70% |
Indian Journal of Dental Research | 7 | 1.70% |
BMC Oral Health | 6 | 1.46% |
Total (Articles) | 412 | 100% |
TOP 10 FIRST AUTHORS | ||
Johns, D. A. | 4 | 0.97% |
Jadhav, G.R. | 4 | 0.97% |
Torabinejad, M. | 4 | 0.97% |
Meschi, N. | 4 | 0.97% |
Chen, Y. | 3 | 0.73% |
Alawwad, M. | 3 | 0.73% |
Bezgin, T. | 3 | 0.73% |
Shivashankar, V. Y. | 3 | 0.73% |
Nagaraja, S. | 3 | 0.73% |
Hiremath, H. | 3 | 0.73% |
Total (Articles) | 412 | 100% |
PUBLICATION YEAR | ||
2023 | 41 | 9.95% |
2022 | 53 | 12.86% |
2021 | 43 | 10.44% |
2020 | 56 | 13.59% |
2019 | 31 | 7.52% |
2018 | 21 | 5.10% |
2017 | 34 | 8.25% |
2016 | 34 | 8.25% |
2015 | 27 | 6.55% |
2014 | 21 | 5.01% |
2013 | 21 | 5.01% |
2012 | 13 | 3.16% |
2011 | 9 | 2.18% |
2010 | 3 | 0.73% |
2009 | 3 | 0.73% |
2008 | 1 | 0.24% |
2007 | 1 | 0.24% |
2006 | 0 | 0% |
2005 | 0 | 0% |
2004 | 1 | 0.24% |
Total (Articles) | 412 | 100% |
PCC | |
---|---|
Population | Patients and experimental models of endodontic treatment |
Concept | PRF and PRP application |
Context | Endodontic treatment |
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Rebimbas Guerreiro, S.; Marto, C.M.; Paula, A.; Pereira, J.R.d.A.; Carrilho, E.; Marques-Ferreira, M.; Vicente Paulo, S. Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review. Int. J. Mol. Sci. 2025, 26, 5479. https://doi.org/10.3390/ijms26125479
Rebimbas Guerreiro S, Marto CM, Paula A, Pereira JRdA, Carrilho E, Marques-Ferreira M, Vicente Paulo S. Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review. International Journal of Molecular Sciences. 2025; 26(12):5479. https://doi.org/10.3390/ijms26125479
Chicago/Turabian StyleRebimbas Guerreiro, Simão, Carlos Miguel Marto, Anabela Paula, Joana Rita de Azevedo Pereira, Eunice Carrilho, Manuel Marques-Ferreira, and Siri Vicente Paulo. 2025. "Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review" International Journal of Molecular Sciences 26, no. 12: 5479. https://doi.org/10.3390/ijms26125479
APA StyleRebimbas Guerreiro, S., Marto, C. M., Paula, A., Pereira, J. R. d. A., Carrilho, E., Marques-Ferreira, M., & Vicente Paulo, S. (2025). Platelet-Rich Plasma and Platelet-Rich Fibrin in Endodontics: A Scoping Review. International Journal of Molecular Sciences, 26(12), 5479. https://doi.org/10.3390/ijms26125479