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Polyphenols Hazard and Safety Assessment in Human Health and Food Systems

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 3063

Special Issue Editors


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Guest Editor
National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67-103, 400293 Cluj-Napoca, Romania
Interests: nanomaterials; nanotechnology; carbon-based materials preparation and characterization; graphene; green chemistry; electrochemistry; detection protocols; sensors; graphene-based modified electrodes; electrochemical mechanisms; portable sensing solutions; food science; polyphenols; nanomedicine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
National Institute for Research and Development of Isotopic and Molecular Technologies, Donat Street, No. 67–103, RO, 400293 Cluj-Napoca, Romania
Interests: food and beverages authentication; traceability; metabolomics; chemometrics; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Throughout the last few decades, polyphenols—plant-derived functional ingredients with different molecular structures—have become an emerging field of interest as a direct result of growing evidence suggesting their positive involvement in various health-related biological activities, through the regulation of metabolism and cell proliferation, including antioxidant, anti-inflammatory, and anticancer behavior. Besides their therapeutic effects, polyphenols’ qualities have been exploited in the food industry to boost product stability and prevent other molecules’ oxidation. This has resulted in an overestimation of the present understanding of their effects, while disregarding the fact that some polyphenol-rich foods were formerly thought to be inedible and antioxidant supplementation treatments have been linked to negative outcomes such as increased mortality or stroke. The dangers of polyphenol consumption are difficult to estimate because the bulk of risk studies have been conducted in vitro. Furthermore, the absence of established methodologies, the analysis expenses, shelf instability, and a lack of intake benchmarks make it difficult to add label content information. As a result, there is an increasing demand for trustworthy procedures that can provide a rapid and accurate response concerning polyphenol detection and quantification in food and pharmaceutical sectors, and further research is necessary to obtain full insight regarding their molecular mechanism, characterizing the short- and long-term health effects. Therefore, the intent of this Special Issue is to summarize and broaden the knowledge on polyphenol action mechanisms and development of economic and sensitive materials and analytical tools capable of supporting the control of polyphenol content and to explain their potential protective/toxic effects on the human body. We invite authors to submit both original research and review articles based on classic procedures recognized as safety control techniques, as well as the development and validation of new protocols and alternative methods that consist in the involvement of either innovative experimental setups or advanced data processing tools, such as supervised statistical methods or artificial intelligence (AI).

Dr. Lidia Magerusan
Dr. Dana Alina Magdas
Guest Editors

Manuscript Submission Information

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Keywords

  • polyphenols
  • food safety
  • health risk evaluation
  • graphenes-based sensors
  • electrochemical detection
  • chemometrics
  • artificial intelligence
  • metabolomics

Published Papers (2 papers)

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Research

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18 pages, 4636 KiB  
Article
Graphene-Based Electrochemical Sensing Platform for Rapid and Selective Ferulic Acid Quantification
by Lidia Mǎgeruşan, Florina Pogǎcean, Maria-Loredana Soran and Stela-Maria Pruneanu
Int. J. Mol. Sci. 2023, 24(23), 16937; https://doi.org/10.3390/ijms242316937 - 29 Nov 2023
Cited by 3 | Viewed by 767
Abstract
Due to the multitude of physiological functions, ferulic acid (FA) has a wide range of applications in the food, cosmetic, and pharmaceutical industries. Thus, the development of rapid, sensitive, and selective detection tools for its assay is of great interest. This study reports [...] Read more.
Due to the multitude of physiological functions, ferulic acid (FA) has a wide range of applications in the food, cosmetic, and pharmaceutical industries. Thus, the development of rapid, sensitive, and selective detection tools for its assay is of great interest. This study reports a new electroanalytical approach for the quantification of ferulic acid in commercial pharmaceutical samples using a sulphur-doped graphene-based electrochemical sensing platform. The few-layer graphene material (exf-SGR) was prepared by the electrochemical oxidation of graphite, at a low applied bias (5 V), in an inorganic salt mixture of Na2S2O3/(NH4)2SO4 (0.3 M each). According to the morpho-structural characterization of the material, it appears to have a high heteroatom doping degree, as proved by the presence of sulphur lines in the XRD pattern, and the C/S ratio was determined by XPS investigations to be 11.57. The electrochemical performances of a glassy carbon electrode modified with the exf-SGR toward FA detection were tested by cyclic voltammetry in both standard laboratory solutions and real sample analysis. The developed modified electrode showed a low limit of detection (30.3 nM) and excellent stability and reproducibility, proving its potential applicability as a viable solution in FA qualitative and quantitative analysis. Full article
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Review

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35 pages, 8067 KiB  
Review
Electrochemistry of Flavonoids: A Comprehensive Review
by Ana-Maria Chiorcea-Paquim
Int. J. Mol. Sci. 2023, 24(21), 15667; https://doi.org/10.3390/ijms242115667 - 27 Oct 2023
Cited by 6 | Viewed by 1812
Abstract
Flavonoids represent a large group of aromatic amino acids that are extensively disseminated in plants. More than six thousand different flavonoids have been isolated and identified. They are important components of the human diet, presenting a broad spectrum of health benefits, including antibacterial, [...] Read more.
Flavonoids represent a large group of aromatic amino acids that are extensively disseminated in plants. More than six thousand different flavonoids have been isolated and identified. They are important components of the human diet, presenting a broad spectrum of health benefits, including antibacterial, antiviral, antimicrobial, antineoplastic, anti-mutagenic, anti-inflammatory, anti-allergic, immunomodulatory, vasodilatory and cardioprotective properties. They are now considered indispensable compounds in the healthcare, food, pharmaceutical, cosmetic and biotechnology industries. All flavonoids are electroactive, and a relationship between their electron-transfer properties and radical-scavenging activity has been highlighted. This review seeks to provide a comprehensive overview concerning the electron-transfer reactions in flavonoids, from the point of view of their in-vitro antioxidant mode of action. Flavonoid redox behavior is related to the oxidation of the phenolic hydroxy groups present in their structures. The fundamental principles concerning the redox behavior of flavonoids will be described, and the phenol moiety oxidation pathways and the effect of substituents and experimental conditions on flavonoid electrochemical behavior will be discussed. The final sections will focus on the electroanalysis of flavonoids in natural products and their identification in highly complex matrixes, such as fruits, vegetables, beverages, food supplements, pharmaceutical compounds and human body fluids, relevant for food quality control, nutrition, and healthcare research. Full article
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