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Natural Antioxidants 2.0: Extraction, Optimization, Characterization, and Their Biological Activity

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 2657

Special Issue Editors


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Guest Editor
College of Life Science, Sichuan Agricultural University, Ya’an 625014, China
Interests: herbal medicine; natural extract; molecular biology
Special Issues, Collections and Topics in MDPI journals
College of Life Science, Sichuan Agricultural University, Ya’an 625014, China
Interests: essential oil; natural products; bioactive compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural antioxidants, especially polyphenols and polysaccharides, exhibit a wide range of biological effects, including anti-inflammatory, antioxidant, antiaging, antiatherosclerosis, and anticancer properties. Their health benefits are mainly attributed to the antioxidative capacity of quenching free radical species in vitro or triggering the redox-sensitive signaling pathway to alleviate oxidative stress in vivo. In recent years, the exploitation of more efficient, safer, and sustainable extraction techniques for natural antioxidants from fruits, vegetables, herbs, and agro-industrial by-products has attracted particular interest.

The present Special Issue, "Natural Antioxidants 2.0: Extraction, Optimization, Characterization, and Their Biological Activity", aims to collect and publish original research papers and reviews covering recent advances of extraction and separation procedures, including the optimization of conventional extraction, ultrasound-assisted extraction, microwave-assisted extraction, enzymatic-assisted extraction, subcritical water extraction, pressurized liquid extraction, deep eutectic solvent extraction, or aqueous two-phase system separation. Innovative processing strategies to recover natural antioxidants with improved nutritional and biological activities are particularly welcome. Prior to the bioactivities’ evaluation of plant extracts with complex mixtures of natural compounds, quantitative and qualitative analyses are encouraged using analytical methodologies, such as HPLC, HPLC–MS, GC-MS, and NMR. In addition, we cordially invite authors to submit their findings regarding the structure–activity relationship investigation and the elucidation of the mechanisms of action of natural antioxidants.

Topics of interest include, but are not limited to, the following:

  • Green and novel techniques for the extraction and purification processes of natural antioxidants;
  • Chemical profiling and biological activities screening of natural antioxidants;
  • Investigating the structure–activity relationship of natural antioxidants;
  • Exploring mechanisms of action of natural antioxidants.

Dr. Shiling Feng
Dr. Lijun Zhou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antioxidants
  • extraction and purification
  • deep eutectic solvents
  • aqueous two-phase system
  • polyphenols
  • bioactive polysaccharides
  • free radical scavenging
  • stress resistance
  • anti-aging effect

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Published Papers (2 papers)

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Research

18 pages, 2121 KiB  
Article
Lemon Flavonoid Extract Eriomin Improves Pro/Antioxidant Status and Interferes with Cholesterol Metabolism without Affecting Serum Cholesterol Levels in Aged Rats
by Branka Šošić-Jurjević, Slavica Borković-Mitić, Slađan Pavlović, Dragana Vlahović, Marko Miler, Thais Cesar, Vladimir Ajdžanović, Dragan Milenkovic, Frans Stellaard, Svetlana Trifunović, Branko Filipović and Dieter Lütjohann
Int. J. Mol. Sci. 2024, 25(10), 5221; https://doi.org/10.3390/ijms25105221 - 10 May 2024
Viewed by 1107
Abstract
This study aimed to assess the antioxidant capacity of lemon flavonoid extract Eriomin® (LE) and its impact on cholesterol metabolism in the context of healthy aging. We orally treated 24-month-old male Wistar rats with an LE (40 mg/kg) suspended in 0.3 mL [...] Read more.
This study aimed to assess the antioxidant capacity of lemon flavonoid extract Eriomin® (LE) and its impact on cholesterol metabolism in the context of healthy aging. We orally treated 24-month-old male Wistar rats with an LE (40 mg/kg) suspended in 0.3 mL of sunflower oil. At the same time, control groups received an equal volume of sunflower oil (CON) or remained untreated (ICON) daily for 4 weeks. We examined LE’s effects on superoxide dismutase and catalase- and glutathione-related enzyme activities, the concentration of lipid peroxides and protein carbonyls, total oxidant status (TOS) and antioxidant status (TAS), and oxidative stress index (OSI) in the liver, jejunum, and ileum. We also measured total cholesterol, its biosynthetic precursors (lanosterol, lathosterol, desmosterol), its degradation products (bile acid precursors) in the serum, liver, jejunum, and ileum, and serum phytosterols (intestinal absorption markers). LE reduced TOS, TAS, and OSI (p < 0.05) compared with control values, indicating its consistent antioxidant action in all examined organs. LE lowered hepatic desmosterol (p < 0.05) while also reducing 7α- and 24-hydroxycholesterol levels in the liver and ileum (p < 0.01). Serum cholesterol, hepatic gene expression, and the immunostaining intensity of CYP7A1 were unchanged. In conclusion, LE exerted non-enzymatic antioxidant effects and reduced cholesterol degradation, reducing its biosynthesis products, thereby maintaining serum cholesterol levels. Full article
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18 pages, 4905 KiB  
Article
Enhancing Essential Oil Extraction from Lavandin Grosso Flowers via Plasma Treatment
by Ricardo Molina, Carmen López-Santos, Karina Balestrasse, Ana Gómez-Ramírez and Jordi Sauló
Int. J. Mol. Sci. 2024, 25(4), 2383; https://doi.org/10.3390/ijms25042383 - 17 Feb 2024
Cited by 1 | Viewed by 942
Abstract
This study explores the impact of plasma treatment on Lavandin Grosso flowers and its influence on the extraction of essential oils (EOs) via hydrodistillation. Short plasma treatment times enhance the yield of EO extraction from 3.19% in untreated samples to 3.44%, corresponding to [...] Read more.
This study explores the impact of plasma treatment on Lavandin Grosso flowers and its influence on the extraction of essential oils (EOs) via hydrodistillation. Short plasma treatment times enhance the yield of EO extraction from 3.19% in untreated samples to 3.44%, corresponding to 1 min of plasma treatment, while longer treatment times (10 min) show diminishing returns to 3.07% of yield extraction. Chemical characterization (GC/MS and ATR-FTIR) indicates that plasma treatments do not significantly alter the chemical composition of the extracted EOs, preserving their aromatic qualities. Investigations into plasma–surface interactions reveal changes at the nanometer level, with XPS confirming alterations in the surface chemistry of Lavandin Grosso flowers by reducing surface carbon and increasing oxygen content, ultimately resulting in an increased presence of hydrophilic groups. The presence of hydrophilic groups enhances the interaction between the surface membrane of the glandular trichomes on Lavandin Grosso flowers and water vapor, consequently increasing the extraction of EOs. Furthermore, microscopic SEM examinations demonstrate that plasma treatments do not affect the morphology of glandular trichomes, emphasizing that surface modifications primarily occur at the nanoscale. This study underscores the potential of plasma technology as a tool to enhance EO yields from botanical sources while maintaining their chemical integrity. Full article
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