Brain Plasticity Across the Lifespan: Development, Aging, and Implications for Cerebrovascular Health

Dear Colleagues,

Brain plasticity is a remarkable property of the nervous system that remains dynamic throughout our lives, influencing how we learn, adapt to new experiences, and recover from injury. Early developmental stages showcase high degrees of plasticity, where the brain rapidly builds new connections, refines neural networks, and lays the groundwork for lifelong cognitive functions. As we age, this adaptability evolves, and while it may decline in some areas, it does not disappear; instead, the brain employs compensatory strategies to maintain function, emphasizing the importance of ongoing stimulation and healthy lifestyle choices. Crucially, cerebrovascular health—encompassing blood flow, vessel integrity, and overall cardiovascular fitness—underpins our brain’s ability to harness plasticity effectively. Age-related vascular changes, such as reduced cerebral blood flow or increased risk of stroke, can compromise plasticity and accelerate cognitive decline. By supporting vascular health through regular exercise, balanced nutrition, stress management, and prompt medical care for vascular risk factors, we maximize the potential for our brains to adapt, learn, and remain resilient across the lifespan.

Dr. Roxana Surugiu
Prof. Dr. Aurel Popa-Wagner
Topic Editors