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Special Issue "New Insight into B Cell Biology"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 31 March 2023 | Viewed by 502

Special Issue Editor

Prof. Dr. Gabriella Sármay
E-Mail Website
Guest Editor
Department of Immunology, Institute of Biology, Eötvös Loránd University, Budapest, Hungary
Interests: regulation of the immune response; B cells; signaling; receptor cross-talk; regulatory cells; autoimmunity; rheumatoid arthritis
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Special Issue Information

Dear Colleagues,

B cells play a critical role in the development of an immune response. After encountering antigens, B cells differentiate into plasma cells, secreting high-affinity antibodies or memory B cells, providing long-lasting memory. B cells also present antigens to T cells, initiating the T cell response to cognate antigens, produce cytokines, and regulate the immune responses. During their development, B cells are educated to differentiate self from non-self, and thus, they go through several checkpoints controlled by B cell receptors and influenced by innate immune sensors such as toll-like receptors. These processes lead to efficient immune response and protection against invading pathogens while maintaining tolerance against self. In the last decade, deep immune phenotyping of developing B cells has led to the discovery of novel B cell subsets, some of them having a role in B cell pathologies, such as autoimmune and infectious diseases or cancer. Targeting these B cells might be a challenge for developing novel therapies.

B cell development is under the control of different metabolic programs, from the precursor states in the bone marrow to the terminal plasma cell and memory cell differentiation. Revealing metabolic programs of B cells may lead to a better understanding of B cell development and the diverse functions of various subsets, as well as B cell disfunctions causing malignancies and autoimmune diseases.

Regulatory B cells suppress inappropriate immune responses and support immune tolerance through direct cell-to-cell contact and/or through the production of cytokines such as IL-10, TGFβ or IL-35. Dysfunction of Bregs might contribute to the development of autoimmune diseases, uncontrolled inflammation, or tumors. However, little is known about the intracellular pathways, leading to their differentiation and the incidence of metabolic programs. Recent observations highlight the glucose metabolism as an essential factor for the expansion of Breg cells.

Accumulating evidence has revealed that B cells play a dual role in tumor immunity; however, detailed characterization of the relationship between B cells and tumors is urgently needed, as a prerequisite for the development of B-cell-based immunotherapies.

The goal of this Special Issue is to highlight the latest progress achieved in these exciting areas of B cell research in health and disease. Up-to-date review articles and experimental papers are welcome.

Prof. Dr. Gabriella Sármay
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • B cells
  • B cell targeting
  • novel subsets
  • metabolism
  • immune regulation
  • tumour immunity

Published Papers (1 paper)

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ArtinM Cytotoxicity in B Cells Derived from Non-Hodgkin’s Lymphoma Depends on Syk and Src Family Kinases
Int. J. Mol. Sci. 2023, 24(2), 1075; https://doi.org/10.3390/ijms24021075 - 05 Jan 2023
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Receptors on the immune cell surface have a variety of glycans that may account for the immunomodulation induced by lectins, which have a carbohydrate recognition domain (CRD) that binds to monosaccharides or oligosaccharides in a specific manner. ArtinM, a D-mannose-binding lectin obtained from [...] Read more.
Receptors on the immune cell surface have a variety of glycans that may account for the immunomodulation induced by lectins, which have a carbohydrate recognition domain (CRD) that binds to monosaccharides or oligosaccharides in a specific manner. ArtinM, a D-mannose-binding lectin obtained from Artocarpus heterophyllus, has affinity for the N-glycans core. Immunomodulation by ArtinM toward the Th1 phenotype occurs via its interaction with TLR2/CD14 N-glycans on antigen-presenting cells, as well as recognition of CD3γ N-glycans on murine CD4+ and CD8+ T cells. ArtinM exerts a cytotoxic effect on Jurkat human leukemic T-cell line and human myeloid leukemia cell line (NB4). The current study evaluated the effects of ArtinM on murine and human B cells derived from non-Hodgkin’s lymphoma. We found that murine B cells are recognized by ArtinM via the CRD, and the ArtinM stimulus did not augment the proliferation rate or production of IL-2. However, murine B cell incubation with ArtinM augmented the rate of apoptosis, and this cytotoxic effect of ArtinM was also seen in human B cell-lines sourced from non-Hodgkin’s lymphoma Raji cell line. This cytotoxic effect was inhibited by the phosphatase activity of CD45 on Lck, and the protein kinases of the Src family contribute to cell death triggered by ArtinM. Full article
(This article belongs to the Special Issue New Insight into B Cell Biology)
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