Special Issue "New Insight into B Cell Biology"
Deadline for manuscript submissions: 31 March 2023 | Viewed by 502
Interests: regulation of the immune response; B cells; signaling; receptor cross-talk; regulatory cells; autoimmunity; rheumatoid arthritis
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B cells play a critical role in the development of an immune response. After encountering antigens, B cells differentiate into plasma cells, secreting high-affinity antibodies or memory B cells, providing long-lasting memory. B cells also present antigens to T cells, initiating the T cell response to cognate antigens, produce cytokines, and regulate the immune responses. During their development, B cells are educated to differentiate self from non-self, and thus, they go through several checkpoints controlled by B cell receptors and influenced by innate immune sensors such as toll-like receptors. These processes lead to efficient immune response and protection against invading pathogens while maintaining tolerance against self. In the last decade, deep immune phenotyping of developing B cells has led to the discovery of novel B cell subsets, some of them having a role in B cell pathologies, such as autoimmune and infectious diseases or cancer. Targeting these B cells might be a challenge for developing novel therapies.
B cell development is under the control of different metabolic programs, from the precursor states in the bone marrow to the terminal plasma cell and memory cell differentiation. Revealing metabolic programs of B cells may lead to a better understanding of B cell development and the diverse functions of various subsets, as well as B cell disfunctions causing malignancies and autoimmune diseases.
Regulatory B cells suppress inappropriate immune responses and support immune tolerance through direct cell-to-cell contact and/or through the production of cytokines such as IL-10, TGFβ or IL-35. Dysfunction of Bregs might contribute to the development of autoimmune diseases, uncontrolled inflammation, or tumors. However, little is known about the intracellular pathways, leading to their differentiation and the incidence of metabolic programs. Recent observations highlight the glucose metabolism as an essential factor for the expansion of Breg cells.
Accumulating evidence has revealed that B cells play a dual role in tumor immunity; however, detailed characterization of the relationship between B cells and tumors is urgently needed, as a prerequisite for the development of B-cell-based immunotherapies.
The goal of this Special Issue is to highlight the latest progress achieved in these exciting areas of B cell research in health and disease. Up-to-date review articles and experimental papers are welcome.
Prof. Dr. Gabriella Sármay
Manuscript Submission Information
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- B cells
- B cell targeting
- novel subsets
- immune regulation
- tumour immunity