Emerging Strategies in Tuberculosis Drug Discovery
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 25 December 2026 | Viewed by 1095
Editor
Interests: organic synthesis; medicinal chemistry; computational chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the leading causes of death from infectious disease worldwide. The global rise in multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB has rendered many frontline therapies ineffective, underscoring the urgent need for innovative drug discovery strategies. Despite recent advancements, TB drug development continues to face significant challenges, including the pathogen’s complex biology and persistence mechanisms, as well as the lengthy treatment regimens required for effective cure.
This Special Issue, “Emerging Strategies in Tuberculosis Drug Discovery”, aims to showcase cutting-edge scientific and technological advances in the ongoing fight against tuberculosis. We welcome original contributions focused on novel small molecules, repurposed drugs, hybrid pharmacophores, and structure-based drug design. Studies detailing innovative synthetic approaches, high-throughput screening, computational modeling, target validation, and mechanism-of-action elucidation are encouraged. Submissions addressing pharmacokinetics, drug resistance mechanisms, and in vivo efficacy of potential anti-TB agents are also invited.
By bringing together interdisciplinary research efforts, this Special Issue seeks to provide a comprehensive overview of cutting-edge developments that may accelerate the discovery of safe, effective, and affordable anti-tuberculosis agents. We welcome original research articles, reviews, and short communications that contribute to the advancement of TB therapeutics.
Dr. Parvesh Singh
Guest Editor
Manuscript Submission Information
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Keywords
- anti-tuberculosis agents
- MDR-TB
- XDR-TB
- drug repurposing
- hybrid drugs
- high-throughput screening
- structure-based drug design
- drug discovery
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