Cellular Physiology and Aging: Membrane Dynamics, Intracellular Environment and Signaling Pathways

Dear Colleagues,

Over the past two centuries, average life expectancy has doubled in most developed countries. However, the increase in lifespan has not been mirrored by a corresponding extension of healthy life expectancy (healthspan). Aging is not a pathological state but rather represents a major risk factor for the development of several chronic conditions, including cancer, cardiovascular disorders, and neurodegenerative diseases. At the cellular level, aging is characterized by a progressive loss of structural and functional integrity, driven primarily by oxidative stress and inflammation. Alterations in ion channels, membrane transporters, and intracellular signaling pathways play a pivotal role in disrupting cellular homeostasis, thereby contributing to the overall decline in organismal function associated with aging. Understanding these processes at the molecular level is essential for identifying potential targets for therapeutic intervention.

This Special Issue of the International Journal of Molecular Sciences seeks to gather original research articles and comprehensive reviews that elucidate the molecular mechanisms underlying age-related changes in membrane dynamics, redox homeostasis, and intracellular signaling. By integrating current knowledge and recent advances, our aim is to provide a holistic overview of the molecular pathways involved in aging and to highlight strategies for preventing, delaying, or potentially reversing the physiological and biochemical alterations that contribute to the onset of age-related diseases.

Dr. Alessia Remigante
Prof. Dr. Rossana Morabito
Dr. Sara Spinelli
Guest Editors

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