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Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention

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Guest Editor
UMass Chan Medical School, Worcester, MA 01605, USA
Interests: liver injury; DILI liver toxicity; MASH; immunology; oncology; computational pathology; spatial transcriptomics; computational genomics; artificial intelligence
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Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to advancing the understanding of liver diseases by delving into their underlying causes, intricate molecular mechanisms, and innovative strategies for treatment and prevention. Liver diseases—including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and gut–liver axis, spleen–liver axis, and alcoholic liver disease, as well as cirrhosis—continue to pose significant challenges to global health. This issue highlights groundbreaking research on the pathophysiology of liver disorders, the roles of genetics, epigenetics, and molecular pathways involved in liver injury and repair. It also focuses on advancements in therapeutic interventions, such as pharmacological treatments, gene therapy, biomarker-guided strategies, emerging biotechnologies, and lifestyle modifications. By integrating diverse perspectives on etiology, molecular biology, and clinical approaches, this collection aims to promote interdisciplinary collaboration, bridge knowledge gaps, and ultimately provide actionable insights to improve patient care and outcomes.

Dr. Munish Puri
Guest Editor

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Keywords

  • liver diseases
  • pathophysiology
  • molecular mechanisms
  • genetics and epigenetics
  • non-alcoholic fatty liver disease (NAFLD)
  • hepatitis
  • liver injury and repair
  • gene therapy
  • pharmacological interventions
  • treatment and prevention
  • gut–liver axis
  • spleen–liver axis
  • alcoholic liver disease

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Published Papers (1 paper)

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Review

31 pages, 4738 KB  
Review
Genome-Based Mexican Diet Bioactives Target Molecular Pathways in HBV, HCV, and MASLD: A Bioinformatic Approach for Liver Disease Prevention
by Leonardo Leal-Mercado, Arturo Panduro, Alexis José-Abrego and Sonia Roman
Int. J. Mol. Sci. 2025, 26(18), 8977; https://doi.org/10.3390/ijms26188977 - 15 Sep 2025
Viewed by 1225
Abstract
Viral hepatitis B and C (HBV and HCV) and metabolic dysfunction-associated steatotic liver disease (MASLD) are major public health concerns in Mexico, driving liver cirrhosis and hepatocellular carcinoma. The Genome-based Mexican (GENOMEX) diet, rich in bioactive compounds, may provide a nutritional strategy for [...] Read more.
Viral hepatitis B and C (HBV and HCV) and metabolic dysfunction-associated steatotic liver disease (MASLD) are major public health concerns in Mexico, driving liver cirrhosis and hepatocellular carcinoma. The Genome-based Mexican (GENOMEX) diet, rich in bioactive compounds, may provide a nutritional strategy for preventing and managing liver disease. This study combines a literature review with integrative bioinformatic analyses to map the antiviral and hepatoprotective mechanisms activated by GENOMEX-derived bioactives and assess their therapeutic potential for preventing and managing liver disease. A literature-based review integrated with bioinformatics to identify the pathways activated by nutrients and bioactive compounds of the GENOMEX diet against HBV, HCV, and MASLD, incorporating data from in silico, in vitro, in vivo, and clinical studies, was conducted. An integrative bioinformatic approach, incorporating the Comparative Toxicogenomic Database and Functional Enrichment Analysis (STRING, DAVID, and Enrichr), was used to identify links between genes, nutrients, and bioactive compounds, with a subset of Mexican food staples included in the GENOMEX diet. The GENOMEX diet includes bioactive nutrients that may modulate molecular pathways related to immune response, oxidative stress, nutrient metabolism, and inflammation. Through integrative analysis, we identified key molecular targets—including TNF, PPARA, TP53, and IL6—that are implicated in viral replication, MASLD progression, and hepatocarcinogenesis. Functional enrichment revealed that these traditional Mexican foods and their nutrients are associated with genes and pathways involved in viral infection, metabolic dysfunction, fibrosis, and liver cancer. These findings highlight that the gene–nutrient interactions of the Mexican staple food in the GENOMEX diet can be integrated into nutritional strategies to prevent and manage HBV, HCV, and MASLD, while reducing fibrosis and HCC progression. These strategies are especially relevant in regions where antiviral treatments are limited due to high costs, antiviral resistance, and an escalating mismatch between the population’s evolutionary genetics and modern environment. Full article
(This article belongs to the Special Issue Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention)
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