Triosephosphate Isomerase: Potential Target in Cancer Treatment and Other Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 24 April 2026 | Viewed by 1527
Special Issue Editor
Interests: protein structure and function; oligosaccharides and health; natural polymers; natural polysaccharides
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cancer is one of the leading causes of death worldwide, and the burden of cancer incidence and mortality is rapidly growing. Many drugs are currently used, but treatments can cause severe side effects. Increased glycolytic activity is characteristic of cancer cells, and triosephosphate isomerase (TPI) is essential for net ATP production in the glycolytic pathway.
Cancer usually implies an overexpression of TPI, and some post-translational events causing functional and structural alterations of TPI have also been described. Such differences represent an opportunity to develop new strategies against cancer. Mounting evidence indicates that TPI is a multitasking protein of importance in the physiopathology of several kinds of cancer and other diseases.
Since TPI is a key enzyme in the metabolism of all glycolytic cells, it becomes an important therapeutic target in many ways. Therefore, this Special Issue aims to provide a forum for those who study TPI as a potential target for treating cancer and other diseases. Discovering TPI's role in human diseases will bring us closer to more effective and safer treatments.
Dr. Gabriel López-Velázquez
Guest Editor
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Keywords
- cancer
- glycolytic
- triosephosphate isomerase
- TPI
- post-translational modification
- cancer treatment
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