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Molecular Research on Nanotoxicology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 148

Special Issue Editor

Institute of Physics of the Czech Academy of Sciences, 182 00 Prague, Czech Republic
Interests: nanotoxicology; cell biophysics; cell mechanics; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite decades of extensive research, the development of novel nanomaterials is still in progress, opening new avenues for biomedical applications. The potential adverse reactions and toxicity of the growing number of novel nanomaterials applied in various biomedical fields introduce concerns. In order to ameliorate the potential adverse reactions of nanomaterials and increase their successful translation to real-world applications, it is crucial to understand the basic molecular mechanisms that drive toxic and adverse reactions.

Therefore, this Special Issue is dedicated to papers from all over the world that deal with nanotoxicology and/or the adverse reactions of nanomaterials utilized in healthcare.

Dr. Oleg Lunov
Guest Editor

Manuscript Submission Information

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Keywords

  • nanotoxicology
  • nanodrugs
  • nanoparticles
  • adverse drug reactions
  • cytotoxicity

Published Papers (1 paper)

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Research

17 pages, 3627 KiB  
Article
Encapsulation of Nanoparticles with Statistical Copolymers with Different Surface Charges and Analysis of Their Interactions with Proteins and Cells
by Saad Megahed, Nicole Wutke, Yang Liu, Markus Klapper, Florian Schulz, Neus Feliu and Wolfgang J. Parak
Int. J. Mol. Sci. 2024, 25(10), 5539; https://doi.org/10.3390/ijms25105539 (registering DOI) - 19 May 2024
Abstract
Encapsulation with polymers is a well-known strategy to stabilize and functionalize nanomaterials and tune their physicochemical properties. Amphiphilic copolymers are promising in this context, but their structural diversity and complexity also make understanding and predicting their behavior challenging. This is particularly the case [...] Read more.
Encapsulation with polymers is a well-known strategy to stabilize and functionalize nanomaterials and tune their physicochemical properties. Amphiphilic copolymers are promising in this context, but their structural diversity and complexity also make understanding and predicting their behavior challenging. This is particularly the case in complex media which are relevant for intended applications in medicine and nanobiotechnology. Here, we studied the encapsulation of gold nanoparticles and quantum dots with amphiphilic copolymers differing in their charge and molecular structure. Protein adsorption to the nanoconjugates was studied with fluorescence correlation spectroscopy, and their surface activity was studied with dynamic interfacial tensiometry. Encapsulation of the nanoparticles without affecting their characteristic properties was possible with all tested polymers and provided good stabilization. However, the interaction with proteins and cells significantly depended on structural details. We identified statistical copolymers providing strongly reduced protein adsorption and low unspecific cellular uptake. Interestingly, different zwitterionic amphiphilic copolymers showed substantial differences in their resulting bio-repulsive properties. Among the polymers tested herein, statistical copolymers with sulfobetaine and phosphatidylcholine sidechains performed better than copolymers with carboxylic acid- and dimethylamino-terminated sidechains. Full article
(This article belongs to the Special Issue Molecular Research on Nanotoxicology)
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