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Molecular and Therapeutic Advances in Organ Toxicity and Metals

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 4198

Special Issue Editors


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Guest Editor

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Guest Editor
Department of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, 98125 Messina, Italy
Interests: neurooncology; brain tumor; drug delivery; glioma; target therapy

Special Issue Information

Dear Colleagues,

Exposure to environmental pollutants such as metals can result in pathophysiological situations in the body. In fact, new knowledge on the molecular aspects of organ toxicity could help the scientific community to understand the pathophysiology of many metal-induced diseases.

Furthermore, new scientific evidences in this area are necessary in designing efficient therapeutic approaches that are required for the normal physiological functions of the body.

In this regards, natural compounds have received increasing attention due to their considerable pharmaceuticals benefits for human health, in particular nutraceutical substances. This Special Issue will shape the future research direction of molecular and therapeutic advances in organ toxicity induced of metals. Our purpose is to feature high-quality, advanced research and knowledge contributed by various research groups working on metals from all around the world. We cordially invite authors to contribute original articles as well as review papers on the pathways of molecular and therapeutic aspects of organ toxicity induced of metals for preventing and managing some human diseases.

Prof. Dr. Letteria Minutoli
Dr. Maria Caffo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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14 pages, 5370 KiB  
Article
Beta-Caryophyllene, a Plant-Derived CB2 Receptor Agonist, Protects SH-SY5Y Cells from Cadmium-Induced Toxicity
by Federica Mannino, Giovanni Pallio, Chiara Imbesi, Alessandro Scarfone, Domenico Puzzolo, Antonio Micali, José Freni, Francesco Squadrito, Alessandra Bitto, Letteria Minutoli and Natasha Irrera
Int. J. Mol. Sci. 2023, 24(20), 15487; https://doi.org/10.3390/ijms242015487 - 23 Oct 2023
Cited by 2 | Viewed by 1203
Abstract
Cadmium (Cd) is a transition heavy metal that is able to accumulate in the central nervous system and may induce cell death through reactive oxygen species (ROS)-mediated mechanisms and inactivating the antioxidant processes, becoming an important risk factor for neurodegenerative diseases. The antioxidant [...] Read more.
Cadmium (Cd) is a transition heavy metal that is able to accumulate in the central nervous system and may induce cell death through reactive oxygen species (ROS)-mediated mechanisms and inactivating the antioxidant processes, becoming an important risk factor for neurodegenerative diseases. The antioxidant effects of cannabinoid receptor modulation have been extensively described, and, in particular, β-Caryophyllene (BCP), a plant-derived cannabinoid 2 receptor (CB2R) agonist, not only showed significant antioxidant properties but also anti-inflammatory, analgesic, and neuroprotective effects. Therefore, the aim of the present study was to evaluate BCP effects in a model of Cd-induced toxicity in the neuroblastoma SH-SY5Y cell line used to reproduce Cd intoxication in humans. SH-SY5Y cells were pre-treated with BCP (25, 50, and 100 μM) for 24 h. The day after, cells were challenged with cadmium chloride (CdCl2; 10 μM) for 24 h to induce neuronal toxicity. CdCl2 increased ROS accumulation, and BCP treatment significantly reduced ROS production at concentrations of 50 and 100 μM. In addition, CdCl2 significantly decreased the protein level of nuclear factor erythroid 2–related factor 2 (Nrf2) compared to unstimulated cells; the treatment with BCP at a concentration of 50 μM markedly increased Nrf2 expression, thus confirming the BCP anti-oxidant effect. Moreover, BCP treatment preserved cells from death, regulated the apoptosis pathway, and showed a significant anti-inflammatory effect, thus reducing the pro-inflammatory cytokines increased by the CdCl2 challenge. The results indicated that BCP preserved neuronal damage induced by Cd and might represent a future candidate for protection in neurotoxic conditions. Full article
(This article belongs to the Special Issue Molecular and Therapeutic Advances in Organ Toxicity and Metals)
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Review

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24 pages, 1006 KiB  
Review
The Role of Selenium and Manganese in the Formation, Diagnosis and Treatment of Cervical, Endometrial and Ovarian Cancer
by Anna Golara, Mateusz Kozłowski, Paweł Guzik, Sebastian Kwiatkowski and Aneta Cymbaluk-Płoska
Int. J. Mol. Sci. 2023, 24(13), 10887; https://doi.org/10.3390/ijms241310887 - 29 Jun 2023
Cited by 5 | Viewed by 2553
Abstract
Selenium (Se) and manganese (Mn) are essential micronutrients that are important elements of cell metabolism. They are involved in the composition of enzyme systems and regulate enzyme activity. Disturbances in the homeostasis of these micronutrients affect the development of many diseases and carcinogenesis, [...] Read more.
Selenium (Se) and manganese (Mn) are essential micronutrients that are important elements of cell metabolism. They are involved in the composition of enzyme systems and regulate enzyme activity. Disturbances in the homeostasis of these micronutrients affect the development of many diseases and carcinogenesis, which can be linked to increased levels of oxidative stress and impaired antioxidant properties of many enzymes. Selenium has a very important function in maintaining immune-endocrine, metabolic and cellular homeostasis. Manganese, on the other hand, is important in development, digestion, reproduction, antioxidant defense, energy production, immune response and regulation of neuronal activity. We review the role of selenium and manganese and their effects on tumor growth, metastasis potential and remodeling of the microenvironment. We also describe their role as potential biomarkers in the diagnosis and the potential for the use of Se- and Mn-containing compounds in composition for the treatment of cancer of the reproductive organs. Full article
(This article belongs to the Special Issue Molecular and Therapeutic Advances in Organ Toxicity and Metals)
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