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Natural Antioxidants in Human Health and Disease, 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 15 July 2024 | Viewed by 1417

Special Issue Editor

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Guest Editor

Special Issue Information

Dear Colleagues,

Oxidative stress, defined as an overproduction of reactive oxygen (ROS) and nitrogen species (RNS) in cells and tissues, plays a pathogenic role in the development of several inflammatory chronic diseases, especially in the case of atherosclerosis, hypertension, obesity, diabetes, metabolic syndrome, and cancer. The increase in ROS and RNS can cause oxidative damage and tissue dysfunction due to structural damage to macromolecules, giving rise to senescent and degenerative lesions in cells. Natural compounds are a source of exogenous antioxidants possibly useful in the management of these pathologies. They have long been considered antioxidant molecules, and most of their benefits have been related to their free radical scavenging properties. Recent findings have shown that these compounds have multiple mechanisms of action in the treatment or prevention of oxidative disorders. Natural antioxidants could interact in humans with pleiotropic effects on a variety of tissues involved in stress response pathways. However, their diversity and chemical complexity mean that much remains to be understood about the mechanisms by which these compounds influence health.

This Special Issue is a collection of research and review articles on the preclinical and clinical benefits of natural antioxidants, with special interest in human health and disease. The aim of this Special Issue is to collect literature that reflects the actual state of the art and increase our knowledge of natural antioxidants and the mechanism of action in their physiological and pathophysiological role. Further, their bioavailability and biotransformation events should be considered to identify the most likely final effectors in cells and tissues.

As the Guest Editor of this Special Issue, I cordially invite researchers from all around the world to contribute by submitting original research articles, long and mini review papers, short notes, and opinions in accordance with their expertise.

Dr. María Herranz-López
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • ROS
  • oxidative disorders
  • molecular pathways
  • inflammation
  • biotransformation

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Published Papers (1 paper)

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14 pages, 3827 KiB  
The Anti-Inflammatory Potential of an Ethanolic Extract from Sarcopoterium spinosum Fruits for Protection and/or Counteraction against Oxidative Stress in Dysfunctional Endothelial Cells
by Hawraa Zbeeb, Francesca Baldini, Lama Zeaiter and Laura Vergani
Int. J. Mol. Sci. 2024, 25(3), 1601; https://doi.org/10.3390/ijms25031601 - 27 Jan 2024
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Plants and plant extracts are a relevant source of bioactive compounds widely employed as functional foods. In the Mediterranean area, the shrub Sarcopoterium spinosum is traditionally used as an herbal medicine for weight loss and a diabetes treatment. Inflammation is a protective mechanism [...] Read more.
Plants and plant extracts are a relevant source of bioactive compounds widely employed as functional foods. In the Mediterranean area, the shrub Sarcopoterium spinosum is traditionally used as an herbal medicine for weight loss and a diabetes treatment. Inflammation is a protective mechanism involved in the development of many pathological conditions, including cardiovascular diseases. The present study aimed to investigate in vitro the antioxidant and cytoprotective properties of an ethanolic extract from S. spinosum fruits (SEE) in a cellular model of endothelium dysfunction. Corilagin and quercetin are two polyphenols abundant in SEE and were tested for comparison. The exposure of HECV cells for 24 h to 30 µM hydrogen peroxide (H2O2) lead to an oxidative stress condition. When HECV cells were treated with 10 µg/mL of SEE or single compounds after or before the oxidative insult, the results showed their ability to (i) decrease the reactive oxygen species (ROS) production quantified using fluorometric analysis and the lipid peroxidation measured with a spectrophotometric assay; (ii) rescue both the glutathione reduced to oxidized (GSH/GSSG) ratio and nitric oxide impair and the protein denaturation; and (iii) accelerate the wound repair measured using a T-scratch assay. Taken together, our findings indicate that the ethanolic extract from S. spinosum fruits could be a potential candidate for nutraceutical application. Full article
(This article belongs to the Special Issue Natural Antioxidants in Human Health and Disease, 2nd Edition)
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