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Flavonoids and Their Impact on Human Health 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 August 2024 | Viewed by 1735

Special Issue Editor

Special Issue Information

Dear Colleagues,

There is an enormous growth of worldwide interest in nutraceutical compounds in both developed and developing countries over the last two decades, increasing the interest of pharmaceutical companies, which has in turn motivated preclinical pharmacological studies as well as controlled and randomized clinical trials to prove the safety and efficacy of these products. Flavonoids are the most studied class of nutraceutical compounds for their impact on human health due to the unquestionable promising biological and pharmacological activities, as shown by epigenetic research, too. These compounds are able to modulate the intracellular signal cascade, and in addition to their well-known antioxidant activity, they can be utilized to promote cell survival or death, focusing their action on a well-defined biological target. USDA, NIH, and several other government and health agencies encourage people to consume a variegated and healthy balanced diet, rich in polyphenols, taking into account the potential health-promoting effects and supported by the evidence supplied by numerous epidemiological studies. Taken together, these characteristics make the daily assumptions of flavonoids a natural defense weapon to promote organisms’ wellness. Taking into account the strong interest in polyphenols as an emerging challenge for the development of health-promoting compounds and potential biotechnological applications, this Special Issue will cover a wide variety of areas, aiming to contribute to the overall knowledge of the molecular mechanism of flavonoids action by multiple points of view on both in producers and in consumers.

Please do note that papers that only focus on extraction do not qualify for this IJMS Special Issue. The focus is not only on the chemical composition of these ingredients, but, more specifically, on describing their mechanism of action in improving human nutrition.

Prof. Dr. Davide Barreca
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • flavonoids
  • antioxidants
  • activation/block of signal cascade
  • modulation of key metabolic enzymes
  • oxidative stress
  • biological potentials
  • antimicrobial activity
  • antiviral potential
  • anticancer activity
  • anti-aggregative activity
  • anti-inflammatory activity

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Published Papers (1 paper)

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15 pages, 5326 KiB  
Therapeutic Effect and Safety Evaluation of Naringin on Klebsiella pneumoniae in Mice
by Guanyu Zhao, Qilin Huang, Xiaohan Jing, Lina Huang, Chen Liu, Xiangyi Pan, Zhaorong Li, Sifan Li, Zhengying Qiu and Ruihua Xin
Int. J. Mol. Sci. 2023, 24(21), 15940; https://doi.org/10.3390/ijms242115940 - 3 Nov 2023
Cited by 1 | Viewed by 1176
Critically ill patients with Corona Virus Disease 2019 (COVID-19) often develop secondary bacterial infections that pose a significant threat to patient life safety, making the development of drugs to prevent bacterial infections in the lungs critical to clinical care. Naringin (NAR) is one [...] Read more.
Critically ill patients with Corona Virus Disease 2019 (COVID-19) often develop secondary bacterial infections that pose a significant threat to patient life safety, making the development of drugs to prevent bacterial infections in the lungs critical to clinical care. Naringin (NAR) is one of the significant natural flavonoids rich in Pummelo Peel (Hua Ju Hong), with anti-inflammatory, antimicrobial, and antioxidant activities, and is commonly used in treating respiratory tract infectious diseases. In this study, the in vitro and in vivo findings revealed that, after Klebsiella pneumoniae (Kpn) infection, NAR inhibited overactivation of the nuclear factor kappa-B(NF-κB) signaling pathway in alveolar macrophages of mice, reduced neutrophil (NEs) recruitment, and lowered the induced production of proinflammatory markers, such as Interleukin-6(IL-6) and tumor necrosis factor α(TNF-α). Thus, it suppressed excessive immune responses in the lungs, as well as attenuated the induced pulmonary fibrosis and inflammatory infiltrates. These results suggest that NAR has a preventive effect against Kpn in mice. In addition, the study evaluated NAR’s potential toxicity, demonstrating that NAR is safe at effective doses. These results suggested that NAR effectively reduces excessive inflammatory damage in the lungs induced by Kpn and enhances the body’s ability to clear bacteria. Therefore, NAR may be an effective and safe healthcare drug for preventing and caring for bacterial pneumonia. Full article
(This article belongs to the Special Issue Flavonoids and Their Impact on Human Health 2.0)
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