Inflammation and Tumor Progression: Signaling Pathways and Targeted Intervention 2.0

Dear Colleagues,

Cancer is still one of the leading causes of death despite remarkable advances in diagnostics and therapy represented by targeted treatments in recent decades. Multi-faceted approaches and better access are further required for complicated tumor patients. One such approach is therapeutic intervention targeting the signaling network formed between the cancer and inflammatory-related immune cells in the tumor microenvironment. A tumor is formed as a result of chronic inflammation that promotes malignant cellular transformation. Tumor cells are influenced by the surrounding tumor microenvironment; several pro-inflammatory mediators and chemokines have been shown to participate in tumorigenesis, even in its pleiotropic roles in biological processes. Therefore, immunological modulation of cytokine-mediated inflammation has been determined in malignant tumors, and it has shown tumor immune evasion.

This Special Issue aims to collect recent topics and aspects of cross-talk between tumor and inflammatory immune cells. In addition, it will discuss the relationship between metastasis and its drug resistance to anti-cancer agents. The knowledge developed may finally lead to breakthroughs in treating chronic and complicated tumor cells. We welcome experts in this field to contribute with original research, mini and full reviews, and perspectives.

Dr. Sunga Choi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.