Innovations in Seizure Management: Exploring New Antiseizure Medications and Targeted Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 2276
Special Issue Editors
Interests: neurology; epilepsy; neurogenetic
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epilepsy treatment has undergone notable advancements owing to novel pharmacological approaches and targeted therapies, spanning across age groups from adults to children. This shift towards precision medicine aims to tackle the diverse etiologies of epilepsy and individual patient responses. By emphasizing personalized treatment strategies such as therapeutic drug monitoring and the integration of pharmacogenomic data, clinicians can optimize therapy efficacy and safety.
This Special Issue of IJMS will focus on the recent developments in pharmacological treatments for epilepsy, highlighting the potential of targeted therapy to revolutionize patient care. By targeting the specific molecular pathways underlying seizure disorders, these therapies offer promising avenues for seizure control and an enhanced quality of life. Additionally, the incorporation of precision medicine principles into clinical practice has the potential of tailoring treatment regimens, minimizing adverse reactions, and optimizing therapeutic outcomes.
Furthermore, epilepsy encompasses various medical conditions characterized by recurrent seizures, presenting a management challenge due to the plethora of syndromes, seizure types, and variable treatment responses among individuals. Over the past two decades, genetic etiology has been unveiled in over half of all epilepsies, with single gene defects in ion channels or neurotransmitter receptors associated with the most inherited forms. The advent of genetic tests, ranging from targeted assays to whole exome and whole genome sequencing, has propelled genetic discovery in epilepsy, shedding light on molecular mechanisms and providing targets for precision medicine in select syndromes. While precision medicine in epilepsy has primarily focused on seizure control, addressing neurodevelopmental and neuropsychiatric comorbidities remains a future avenue. This Special Issue aims to explore the recent advances in genetic testing and outline the tailored treatments applicable to some monogenic epilepsies, envisioning a future where epilepsy treatment adopts a widespread precision medicine approach.
Dr. Antonio Gennaro Nicotera
Prof. Dr. Gabriella Di Rosa
Guest Editors
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Keywords
- antiseizure medications
- targeted therapies
- epilepsy
- monogenic epilepsies
- new antiseizures medications
- developmental and epileptic encephalopathies
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